Migraine

Question 1

Hemiplegic Migraine Diagnostic Criteria

Answer 1

3 attacks
Migraine with aura criteria , and
BOTH reversible motor weakness AND visual, sensory, or speech symptoms

Question 2

FHM 1 mutation

Answer 2

CACNA1A (Calcium channel) on chromosome 19

Question 3

FHM 2 mutation

Answer 3

ATP1A2 (K/Na ATP-ase) on chromosome 1

Question 4

FHM 3 mutation

Answer 4

SCN1A (Na channel) on chromosome 2

Question 5

FHM 1 associated genetic syndromes

Answer 5

Episodic ataxia type 2
SCA type 6
Exploding head syndrome

Question 6

FHM 2 associated genetic syndromes

Answer 6

Alternating hemiplegia of childhood

Benign familial infantile epilepsy, other sz

Question 7

FHM 1 other symptoms

Answer 7

Ataxia - cerebellar atrophy in 50%

Nystagmus, coma, prolonged hemiplegia

Question 8

FHM 2 other symptoms

Answer 8

Seizures, SNHL, ID, coma, hemiplegia

Question 9

FHM 3 associated genetic syndromes

Answer 9

Dravet, GEFS+, migrating partial epilepsy of infancy, Doose

Question 10

FHM 4 mutation

Answer 10

PRRT 2

Question 11

FHM 4 associated genetic syndromes

Answer 11

PKD (paroxysmal kinesigenic dyskinesia)

ICCA (infantile convulsions and choreoathetosis)