Antinuclear antibodies

Question 1

Anti Ro/SS most strongly a/w

Answer 1

• Sjogren syndrome (70%)
• neonatal lupus (100%)
• but, can also be seen in SCLE (75%-90%) and SLE (50%)

Question 2

Anti La/SSB most strongly a/w:

Answer 2

• Sjogren syndrome (40%)

- but also seen in SCLE

Question 3

Anti SCL-70 is aka:

Answer 3

DNA topoisomerase I

Question 4

Anti SCL-70 (DNA topoisomerase I) is most strongly a/w:

Answer 4

• diffuse SSc (60%)

Question 5

Anti Jo-I is a/w:

Answer 5

• Dermatomyositis/polymyositis

Question 6

Anti smith ab is highly _____ for SLE

Answer 6

• specific (only 30% sensitive)

Question 7

very high titers of anti RNP antibodies is a/w:

Answer 7

MCTD

Question 8

anti dsDNA ab is highly specific for ______

Answer 8

SLE

Question 9

antibody a/w drug induced lupus:

Answer 9

• anti histone

Question 10

Antibody a/w CREST:

Answer 10

• Anti Centromere (80%)

Question 11

ANA is considered positive if dilution of ____

Answer 11

> 1:40

- about 20-30% of healthy people have 1:40

Question 12

What percentage of healthy people have ANAs around 1:40?

Answer 12

20-30%

Question 13

What percent of SLE patients will have positive ANA:

Answer 13

• 99%

Question 14

What will lupus band test show in SLE?

Answer 14

• Granular continuous band of IgM>IgG>IgA and C3 at DEJ

Question 15

Which lupus band test correlates with anti-dsDNA abs and is a/w severe extracutaneous disease including renal?

Answer 15

• Sun-protected, non-lesional skin lupus band test