Hypothalamic/pituitary drugs: Prolactin, GnRH, LH/FSH, TRH, and CRH Flashcards
What disorders can cause hyperprolactinemia?
Pituitary adenomas or diseases that decrease dopamine signaling (parkinson’s)
What are the effects of hyperprolactinemina?
Galactorrhea - women Amenorrhea - women Infertility in women/men loss of libido - men Impotence - men
What are the treatments for hyperprolactinemia?
- Surgery
- Radiation
- Dopa receptor agonist
What are the D2 receptor agonists?
Cabergoline (high affinity)
Bromocriptine (Poorly tolerated)
What is the normal physiological function of GnRH?
GnRH stimulates the release of LH and FSH from the anterior pituitary.
For what therapeutic uses are exogenous LH and FSH used for?
Infertility and hypogonadism in women
Infertility in men.
What are the Goserelin, Triptorelin, and Leuproloide?
They are GnRH agonists used for prostate cancer.
What are the effects of Goserelin, Triptorelin, and Leuproloide?
- Increased LH initially
2. decreased LH and testosterone subsequently by decreased receptors.
What is HIstareline?
GnRH agonist that decreases LH receptors leading to precocious puberty.
What is Nafarelin?
GnRH agonist used for precocious puberty and endometriosis.
What is different about synthetic GnRH compared to natural GnRH?
Synthetic GnRH with aa substitutions that increase its T1/2 and receptors binding affinity.
What is Human excreted CG?
Purified pregnant piss that mimics LH. Typically used to treat infertile women.
What is menotropin?
Purified old lady piss that contains LH and FSH. IM injections are given to treat infertility in women.
For what is recombinant FSH used for?
To treat infertility in women.
What are Certrorelix and Ganirelix?
They are GnRH antagonists used for in vitro fertilization. They function by delaying the LH surge and ovulation.
