Viral Hepatitis Testing

Question 1

What is viral hepatitis?

Answer 1

Inflammatory disease of the liver

Question 2

What liver enzymes are increased in viral hepatitis?

Answer 2

AST, ALT, GGT

Question 3

Order of Hepatitis B antigens and antibodies appearance overtime:

Answer 3

HBsAg –> HBeAg –> Anti-HBc –> Anti-HBe –> Anti-HBs

Question 4

What is the incubation period of Hepatitis B?

Answer 4

8-13 weeks

Question 5

What would you see in the serum of someone who recently was infected with acute Hepatitis A?

Answer 5

Anti-HAV (IgM)

Question 6

What would you see in the serum of someone who has Hepatitis C infection?

Answer 6

Anti-HCV

Question 7

What Hepatitis B antigen is correlated with infectivity and viral replication?

Answer 7

HBeAg

Question 8

What hepatitis B antigens/antibodies are associated with acute Hep B infection (highly infectious!!)

Answer 8

HBsAg
HBeAg

Anti-HBc (IgM)
Anti-HBe

Question 9

What antigens/antibodies would you see in a Chronic Carrier for Hep B?

Answer 9

HBsAg
HBeAg
Anti-HBc (Total)

Question 10

What antigens/antibodies would you see in a person who has conferred immunity to Hep B due to PAST INFECTION / Recovered from Hep B?

Answer 10

Person has immunity now, so you wouldn’t see any antigens.

Would see…
Anti-HBe
Anti-HBc (total)
Anti-HBs

Question 11

What antigens/antibodies would you see in a person who has conferred immunity to Hep B due to VACCINATION?

Answer 11

Anti-HBs