Pharmacology Flashcards
Learn the details of pharmacology
Cytochrome P450 3A4
metabolizes steroids, Ca2+ channel blockers(nifedipine), Benzodiazepine,
Cytochrome p450 2D6
Activates Fluoxetine, metabolizes amitriptyline, ß-blockers (metoprolol), tricyclic antidepressants, dextromethorphan
Cytochrome P450 2C9
hexobarbital, ibuprofen, phenytoin, S-warfarin,
CYP 2C19 *2 mutants slow metabolizers
increased toxicity citalopram prolonged sedation diazepam increased sedation mephenytoin decreased saturation threshold for phenytoin decreased activity of proguanil decreased response to clopidogrel increased effectiveness of omeprazole against H. pylori
CYP 2C9 slow metabolizers
hypersensitive to s-warfarin phenytoin losarthan
CYP1A2*1F
Slow caffeine metabolizers increased risk for non-fatal MI