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Clin Pharm > Drug List > Flashcards

Drug List Flashcards

1
Q

Cyclosporine; group/use, mech of action

A

Immunemodulator

Mech of Action

  • Calcineurin inhibitor that binds to cytoplasmic receptor proteins.
  • inhibits calcineurin, & decreases expression of IL-2 and other cytokines necessary for T-cell activation.
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2
Q

Tacrolimus; group/use, mech of action

A

Immunemodulator

Mech of Action
- Similar to cyclosporine but used topically

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3
Q

Oclacitinib & Apoquel; group/use, mech of action

A

Immunemodulator

Mech of Action

  • Janus Kinase inhibitor
  • Inhibits activity of proinflammatory cytokines (IL-1, IL-4, IL-6, IL13, IL-31*).
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4
Q

Azathioprine; group/use, mech of action

A

Immunemodulator

Mech of Action

  • prodrug that is metabolized to a purine analog (6-mercapto purine).
  • Interferes w/ incorporation of purines or pyrimidines into DNA
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5
Q

Cyclophosphamide; use, mech of action

A

Immunemodulator

Mech of Action

  • alkylate DNA that causes chemical cross-links to occur in DNA
  • interferes w/ DNA replication.
  • None labeled for use in veterinary medicine.
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6
Q

Chlorambucil; use, mech of action

A

Immunemodulator

Mech of Action

  • alkylate DNA that causes chemical cross-links to occur in DNA
  • interferes w/ DNA replication.
  • None labeled for use in veterinary medicine.
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7
Q

Mycophenolate mofetil & Mycophenolic acid; use, mech of action

A

Immunemodulator

Mech of Action

  • inhibits type II isoform of inosine-5’-monophosphate dehydrogenase present in activated lymphocytes.
  • inhibits synthesis of guanosine nucleotides.
  • may also suppress dendritic cell maturation and monocyte recruitment.
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8
Q

Corticosteroids; use

A
  • Immunemodulator

- Anti-inflammatory used for reactive airway Dz (smooth muscle relax)

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9
Q

Slidenafil; use, mech of action

A

used for pulmonary hypertension

Mech of Action

  • type V phosphodiesterase inhibitor
  • produces nitric oxide mediated vasodilation
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10
Q

Cromolyn; use, Mech of Action

A

Anti-inflammatory used for reactive airway Dz

MOA

  • interferes w/ Ca transport across cell membrane
  • inhibits mast cell degranulation
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11
Q

Morphine, codeine, hydrocodone; use, MOA

A

Antitussive

MOA
- depresses cough center in medulla via mu or kappa receptor

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12
Q

Saline Expectorants; use, MOA

A

Expectorant

MOA

  • stimulate gastric mucosa & vagus
  • increase GI & bronchial secretions
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13
Q

Butorphanol; use, MOA

A

anti-tussive

MOA

  • depresses cough center in medulla via mu or kappa receptor
  • partial Mu agonist
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14
Q

Tramadol; use

A

antitussive

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15
Q

Doxapram; use, MOA

A

stimulate resp center in emergency

MOA
- stimulatory affects on carotid & aortic chemoreceptors

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16
Q

Methylxanthines; use, MOA

A

bronchodilator

MOA

  • inhibition of PDE ->
  • inhibits breakdown of cAMP ->
  • decreased release of inflammatory mediators from mast cells ->
  • anti-inflammatory & bronchial smooth muscle relaxation.
  • ALSO adenosine receptor antagonists ->
  • avoid bradycardia and bronchoconstriction.
17
Q

Epinephrine; uses, MOA

A

bronchodilator

MOA

  • stimulate beta 1 & 2 adrenergic receptors ->
  • hypertension & tachycardia
18
Q

Atropine; uses, MOA

A

bronchodilator

MOA
- anticholinergic

19
Q

Glycopyrrolate; uses, MOA

A

bronchodilator

MOA
- anticholinergic

20
Q

Ipratropium bromide

A

bronchodilator

MOA
- anticholinergic

Clin Pharm (8 decks)

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