MIDAZOLAM Flashcards
1
Q
Class
A
Short acting benzodiazepine
2
Q
Mechanism of Action
A
GABA agonist
3
Q
Dose Anesthesia adjunct
A
Sedation:
0.03 - 0.08 mg / kg IV
(1-2 mg)
Can be given IM, IN, PO
4
Q
Onset of action
A
Within 3 - 5 min
5
Q
Peak
A
3 - 5 min
6
Q
Duration
A
~ 1 hr
7
Q
Elimination Half Time
A
Elimination half time is 1-4 hours (short acting)
8
Q
Elimination
A
Metabolized by the liver and excreted by the urine
Caution in alcoholics / liver disease
9
Q
CNS Effects
A
Anxiolytic
Amnesic
Hypnotic
Decreases cerebral blood flow
NO ANALGESIA
10
Q
CVS Effects
A
Neutral: decrease in TPR but minimal effect on Blood Pressure
11
Q
Respiratory Effects
A
Dose dependent respiratory effects
Synergistic with opioids
Response exaggerated in elderly, COPD
12
Q
Misc. Effects
A
Water soluble therefore pain with injection and phlebitis seen with Diazepam is uncommon
