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Antimicrobials > Anti Helminthics > Flashcards

Anti Helminthics Flashcards

1
Q

Anti-helminthics MOAs?

A

NM paralysis of worm
Ca and Cl entry
Metabolism
Microtubular formation

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2
Q

Classification

A

Tape worm: praziquantel
Whipworm: albendazole and mebendazole
Roundworm, hookworm, pinworm: albendazole
Mebendazole, levamisole

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3
Q

Mebendazole MOA?

A

Inhibits B-tubulin which inhibits actin myosin filaments of the worm

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4
Q

Mebendazole spectrum

A

Broad
Intestinal nematodes + cestodes

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5
Q

Mebendazole is taken with ______ + reason

A

Purgative bc expulsion process is slow

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6
Q

Mebendazole ADRs?

A

Hepatotoxic
Worms in nose and mouth

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7
Q

Mebendazole contraindicated in?

A

Early pregnancy
< 2y/o
Hepatic or renal patient

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8
Q

Praziquantel MOA?

A

Inc Ca++ permeability of parasite cell

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9
Q

Praziquantel ADRs?

A

Fever
Lethargy
Diarrhea
Abd pain

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10
Q

Pyrantel pamoate MOA?

A

Depolarise NM junctions

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11
Q

Pyrantel pamoate Spectrum?

A

Nematodes infection

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12
Q

Pyrantel pamoate ADR

A

Rash
GI upset
Headache

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13
Q

Diethylcarmazine is drug of choice for _____

A

Filiarisis

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14
Q

Diethylcarbamazine MOA?

A

Inc phagocytosis

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15
Q

Diethylcarbamazine and ivermectin ADR?

A

Mazzotti rxn

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16
Q

Ivermection MOA?

A

Alters Cl- permeability causing paralysis

17
Q

Ivermectin is a ________

A

GABA agonist

18
Q

Ivermectin spectrum

A

Scabies
Intestinal nematodes
Filiarisis

19
Q

Levamisole MOA

A

Stimulates ganglia which causes tonic paralysis and separates its hooks

20
Q

Levamisole Spectrum

A

Ascaris and akylostoma

21
Q

Levamisole ADRs?

A

Nausea
Drowsiness/insomnia
Abd pain
Fatigue

22
Q

Piperazine MOA

A

NM paralysis

23
Q

Piperazine spectrum

A

Ascaris
Enterobius

24
Q

Piperazine is not taken with a purgative
True or False

A

False

25
Q

Piperazine ADRs

A

Urticaria
Convulsions
Resp failure

26
Q

Which anti helminthic is safe for pregnancy?

A

Piperazine

Antimicrobials (9 decks)

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