Linkage Disequilibrium

Question 1

Haplotype definition

Answer 1

The combination of genes on one chromosome
- gametes are haploid

Question 2

Why is recombination important?

Answer 2

• Maternal and paternal chromosomes carry different alleles
• Both independent assortment and crossing over will produce new allele combinations
• If two or more loci interact natural selection may act on combinations of alleles
• Recombination can act to create and to break up these combinations
• It is an important source of new alleluic combinations

Question 3

Linkage equilibrium is…

Answer 3

• the random association of alleles at different loci

Question 4

Linkage disequilibrium is…

Answer 4

The no random association of alleles at different loci

Question 5

What destroys linkage disequilibrium?

Answer 5

Linkage disequilibrium is lost by recombination
ie. crossing over during meiosis

Question 6

Epistasis definition

Answer 6

The expression of one hereditary character to the exclusion of another when the two are controlled by alleles of different genes; also more widely, any interaction of non allergic genes