L2 ( CYP 2A6 )

Question 1

Complete the sentence:

In addition to the wild type CYP2A6*1, several variants for the CYP2A6 polymorphism have been identified . What are these variants ?

Answer 1

1️⃣ CYP2A62 (single amino acid substitution)
2️⃣ CYP2A64 (gene deletion)
3️⃣ CYP2A65 (gene conversion)
4️⃣ CYP2A620 (frameshift)

Note :
All these four associated with abolished enzyme .

Question 2

True or false?

Deletion of the CYP2A6 gene is very common in Asian patients, which
likely accounts for the dramatic difference in the frequency of PMs in
Asian (20%) versus white populations (≤1%).

Answer 2

True ✅

Question 3

Complete the sentence:

Why the clinical relevance of the CYP2A6 polymorphism lies in management of tobacco abuse.

Answer 3

Because Nicotine is metabolized by CYP2A6.
So , The inability to metabolize nicotine, secondary to the presence of a defective CYP2A6 allele, likely leads to enhanced nicotine tolerance and increased adverse effects from nicotine.

Question 4

True or false?

Nonsmokers were more likely to carry the defective CYP2A6 allele than were
smokers.

Answer 4

True ✅

Question 5

True or false?

Smokers who had the defective CYP2A6 allele smoked fewer cigarettes and were more likely to quit.

Answer 5

True ✅

Question 6

True or false ?

CYP2A6 inhibition may have a role in the management of tobacco dependency

Answer 6

True ✅