Carbapenems Flashcards

1
Q

Carbapenems

A

Imipenem
Meropenem
Ertapenem
Doripenem

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2
Q

Structure of carbapenems

A

penicillin-like structure in which sulfur atom of thaizolidine ring is replaced by carbon atom

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3
Q

What were carbapenems once called?

A

Gorillacillins

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4
Q

What is imipenem inactivated by?

A

Renal dehydropeptidase

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5
Q

What is Imipinem used in combo with

A

cilastatin (dehydropeptidase inhibitor)

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6
Q

Main ADE of carbapenems

A

seizures in patients with epilepsy, anemia, leukopenia, and other blood dyscrasias

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7
Q

DOC Carbapenems

A

ESBL-producing GNRs

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8
Q

Are Carbapenems bactericidal or static?

A

Bactericidal

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9
Q

What types of bacteria are carbapenems used for?

A

a wide range of gram positive and gram negative bacteria

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