Diseases and Disorders of the Urinary System

Question 1

What does urinary system do?

Answer 1

filter the blood, form and stores urine, excrete urine from the body

made of 2 kidney, ureters urinary bladder and urethera

2 kidneys to connected to urinary bladder via ureter to be drained from body via urethra

Question 2

kidney function?

Answer 2

critical for homeostasis bc they remove waste and toxins from blood, regulate water and electrolyte levels and control pH and bp

produce renin (regulates bp and eryhtopietin (stimulate RBC production)

prodces 1mL urine per min (20-25A% of body’s blood volume is in kidney at any time)

Question 3

What is the nephron?

Answer 3

functional unit of kidney (1M in each kideny)

filters metabolic waste products in blood plasma

reabsorbs 99& of water with nutreints (glucose and amino acids)

Question 4

what is excreted by kidney?

Answer 4

Extra water,
excess ions, acid, some drugs, and metabolic
wastes such as urea and creatinine

Question 5

What hormones r important in regulating nephron’s abiltiy to reabsorb salt and water?

Answer 5

aldosterone and antidiuretic hormone (ADH)

Question 6

nephron components?

Answer 6

Afferent arteriole, efferent arteriole, glomerulus, glomerular capsule, proximal convoluted tubule, renal loop (loop of Henle) and distal convoluted tubule that leads to collecting duct

Question 7

how do nephrons work?

Answer 7

carries blood to nephron and enters glomerulus (network of specialized selectively permeable capillaries) where it is filtered into the surrounding glomerular capsule

filtrate has fluid from plasma and some of its constituents

as filtrate continues through proximal renal tubules ➡ renal loop ➡ distal renal tubules water, gluvose and electrolyes is absorbed into nearby capillaires, leaving acid and urea where it enters collecting ducts, forming urine

emters renal calyces and renal pelvis, down ureters to urinary bladder

Question 8

What is checked in history for urinary system?

Answer 8

presence of other diseases (esp diabetes, hypertension and UTI), exposure to meds, antibiotics and kideny toxins or abuse of analgesics such as acetaminophen

pt reports abt fever, pain, urine volume, frequency or color

family history can indicate genetic predispotion ofr certain disease

Question 9

What can be seen in the physical exam as a result of a urinary disease?

Answer 9

edema in skin, around eyes and on ankles

toxin in blood = neurologicc abnormalities such as disorientation and changes in cosciousness and response ot stimuli

changes in electrolyes = hypertension and strong, irregular pulse

alteration in pH lelvels from acidosis = hyperventilation

Question 10

color in urine

Answer 10

color and volume (diabetes = lots of pale and diluted urine)

chronic kidney diseases = abiltiy of renal tubules to concentrate urine is absent so urine is dilute and pale + specific gravity is low

presence of RBC = red-brown color to urine

odor - abn is foul, fruity, pathologic is cysitis or uti, diabetes

chemical nautre - pH is 6.5 (slightly acidic), alkaline meakns infection cause ammonia to form

Question 11

What is studyied in urinalysis and lab tests?

Answer 11

urine speciimen (physically, chemically and microscopically)

physical factors include urine color, clarity, odor, PH and specific gravity

test for RBC, WBC, bacteria, crystals and casts (form within kidney tubules, consist of coagulated protein, blood cells and epithelial cells)

Question 12

Chem tests for urine?

Answer 12

albumin in urine (albuminuria) = inflammation of urinary tact (paticularly of glomeruli)

presence of glucose in the urine of 1 of the signs of diabetes mellitus

Question 13

What are imaging techniques for urinary diseases?

Answer 13

ultrasound and CT for visualization

cytoscopic exam to see inside of bladder and urehtera (long, lighted instrument resembling narrow hollow tube isnterted through urethrra into bladder)

Question 14

What is acute kidney injury?

Answer 14

sudden onset of impaired renal function

Question 15

3 main causes of acute kidney injury?

Answer 15

1. shock (interrupts blood flow to kidney)
2. tubular necrosis (= lots of diseases like systemic lupus erythematosus, sickle cell disease, renal vein thrombosis, acute pststreptococcal glomerulonephritis or exposure to toxins)
3. obsutrctured urine flow (from kidney stones, inflamed prostate or tumor)

Question 16

s/s of acute kideny injury?

Answer 16

oliguria (sudden drop in urine volume)
rarely there is complete stop of urine production (anuria)

N&V
diarrhea, odor of ammonia in breath from accumulation in blood of N-containing compounds
headache, drowsiness, confusion, neuropathy, seizures, and coma

1st low bp occurs, then hypertension and heart failure and respiratory edema

Question 17

what is hyperkalemia?

Answer 17

condition of elevated blood potassium (= cardiac arrest)

Question 18

How to diagnose acute kidney failure?

Answer 18

history, blood tests for elevated blood urea nitrogen, serum creatinine, potassium, low pH (signs of kideny failure)
urnalysis for casts, low specific gravity and pssibly proteinuria,
ultrasound

Question 19

how to treat acute kidney failure?

Answer 19

diet low in protein, sodium and potassium

restricted fluid intake and dialysis (if hyperkalemia than def dialysis and IV meds to removed potassium)

Question 20

What are urinary tract infections (UTIs)

Answer 20

caused by bacteria in skin or color

bacteria that colonize urethra usually become dislodged by regular flow of urine, if not then bacteria ascend the urethra and infect urianry bladder and kidneys

can occur during low urine production, catheterization or poor hygenine

more likely in women bc they have shorter urethras

Question 21

What are the lower UTIs?

Answer 21

urethritis (inflammation of the urethra) and cystitis (inflammation of the urinary bladder)

primary cause is bacterial infection (treatment include antibiitoics)

Question 22

risk factors for lower UTIs?

Answer 22

being female, multiple sex partners and STIs

Question 23

s/s of urethritis?

Answer 23

discharge from urethra, itching sensation at opening of tge urethra and a burning sensation during urination

Question 24

cytsititis s/s

Answer 24

freqent urinary, sense of urinary urgency and dysuria (painfule burning sensation during urination)

low fever, rpessure with pain in lower back

Question 25

how to prevent lower utis?

Answer 25

stay hudrated to promote urine flow, practining front-to-back wiping after urinarting and safe sex

Question 26

What r upper UTIs?

Answer 26

pyelonephritis (inflammation of the kidney (renal pelvis and connective tissues))

infected abscesses form and ruptre = pyuria (pus in urine, = urine is turbid or cloudy)

caused by pyogenes (pus-forming) bacteria such as Escherichia coli, streptococci and staphylococci that ascend from lower UT

obstruction and stasis of urine by renal calcui (kidney stones), tumors, benign prostatic hypertrophy predispose kidneys to infection

Question 27

risk factors for upper UTIs?

Answer 27

being female, kidney stone, urinary catheter or immunodeficiency

Question 28

s/s pyelonephritis?

Answer 28

chills
high fever
N&V
sudden back (flank (lumbar)) pain
dysuria
hematuria and pyuria
tenderness in suprapubic region
abd becomes rigid
palpation may reveal tender, enlraged kidneys
abn constituents, includig urinary casts, nitrites and leukocytes
UTI w/ urinary frequency or urgency and dysuria
numerous pus cells and bacteria
abscess can fuse and fill entire kidney with pus

Question 29

What is lupus nephritis?

Answer 29

inflammatory disease of kidney

occurs in 45% of ppl with systemic lupus ertheomatosus

Question 30

s/s lupus nephritis?

Answer 30

hematuria, hypertension and joint pain

Question 31

how to diagnose lupus nephritis?

Answer 31

pt history, physical exam, evaluation of symptom, lab tests like urinalysis, blood tests, ultrasound, kidney biopsy

Question 32

how to treat lupus nephritis?

Answer 32

antiinflammatory drugs and immune-suppressants

treat hypertension must be treated with statins or ACE inhibitors and reduced-fat and low-salt diet

renal transplant

Question 33

What is IgA nephropathy + age and what it results in?

Answer 33

inflammtory disease of kidney resulting IgA deposition in glomeruli

more common in men from late teens to early 30s

common cause of glomerulonephritis

Question 34

most common s/s of IgA nephropathy?

Answer 34

blood in urine and later, sweelign of the hands and feet

Question 35

how to diagnose and treat IgA nephropathy?

Answer 35

diagnose - test for blood urea nitrogen, urinalusis and renal biopsy

treatment - no treatment in mild cases w/ normal pbp and proteinuria but elevated bp = hypertension meds

Question 36

What is glomerulonephritis (GN)?

Answer 36

inflammatory disease of glmeruli that arises from a variety of underlyind diseases and disorders

2nd leading cause of renal failure

if acute, usually affects children 1-4 wekks following streptococcal infection of skin or throat (can be endogenous as accompaniment of tumors)

chronic = after chronic kidne disease

Question 37

risk factors for glomerulonephritis?

Answer 37

diabetes, hypertension, and
streptococcal infection

Question 38

What is acute poststreptococcal glomerulonephritis?

Answer 38

inflammtory GN caused by antigen-antibody reaction that occurs approx 1-4 wks after streptococcal skin or throat infection

Question 39

how does Acute poststreptococcal GN work?

Answer 39

antigens from streptococci and antibodies form complex in bloodstream that become trapped in glmoruli = inflammatory response and damge = impaired filtration function

Question 40

s/s of acute poststreptococcal GN?

Answer 40

chills
fever
loss of appetiti
gneral feelign of weakness
edema in face and ankles

Question 41

how to dianogse and treat acute poststreptococcal GN?

Answer 41

diagnose = pt history, urinalysis (grpss blood and presence of RBCs, WBCs, renal tubular cells, casts, proteinuria), phyiscal exam, renal bopsy, blood test (elevated blood urea nitrogen (BUN), hypoalbuminemia, elevated ESR, KUB radiography, ultrasonography may reveal Bilateral enlargement of kidney)

treatment - anitbiotic, rest, corticosteroids, usually anti-inflammatory drugs and immune suppressants and may need to treat hypertensoion

Question 42

What are kidney stones?

Answer 42

deposits of minerals within the kidney called urinarly calcuil= urolithis

no symptoms unless larger than 1/4 in in which they become lodged in ureter

men r 4x more likely then women to get it (btwn 20-40)

may cause UTIs

Question 43

s/s of uroliths

Answer 43

intense pain that radiates from kidney to groin area, hematuria, N&V, diarrhea

Question 44

how to diagnose and treat uroliths?

Answer 44

diagnose - CT, renal ultrasound

treat - meds to dissolve stone, lithotripsy (prevent recurrence by increasing fluid intake to keep urine dilute and idetary calcium and protein should be reduced)

Question 45

what is lithotripsy?

Answer 45

crushing of kidney stones with vibrations applied externally and focused internally
successful in 20% of kidney stone
hydrolithotripsy is when pt is submerged in water

Question 46

What is renal failure + risk factors?

Answer 46

progressive loss of kidney function over time

risk factors - diabetes, glomerulonephritis, or other chronic kidney diseases, ischemia, hemorrhage, shock, toxins and large kidney stomes or tumor

Question 47

what occurs in renal failure?

Answer 47

kidney r unable to clear blood of urea and creatinine (nitrogen-contaiing waste products of protein metabolism) - if these accumulate in blood they r toxi

known as uremia

Question 48

How to diagnose and treat renal failure?

Answer 48

diagnose - blood tests for lood urea nitrogen and tests of the glomerular filtration rate (GFR)

treat - depends on cause of renal failure but usually renal dialysis

Question 49

How does GFR work?

Answer 49

GFR determines ability of kidney to clear creatinine

if impaired serum creatinine level rises and creatinine clearance rate falls

Question 50

What is chronic kidney disease + risk factors?

Answer 50

life threatening, v. poorer prognosis than acute kidney injury

gradual and progressive loss of nephroms w/ irreversible loss of renal function and graudal onset of uremia

risk factors r chronic glomerulonephritis, hypertension and diavetic nephropathy, kidney disease resulting from diabetes mellitus

also related to long-term used of ibuprofen and chronic kidney disease

Question 51

What is diabetes nephropathy

Answer 51

most common cause of chronic kidney disease and end-stage renal disease in US

refers to renal changes resulting from diabetes mellitus (alled glomerulosclerosis, can be expected to occur in all pt w/ type I diabetes)

due to inflammation of glomerulus which decreases filtration rate and leaks high levels of albumin and other plasma components into urine = may develop into into diabetes

Question 52

s/s of diabetes nephropathy

Answer 52

develop slowly over 5–10 years and include
fatigue
urinary retention
hypertension
nausea
proteinuria
headache
itching
frothy urine
frequent hiccups
edema, particularly in the legs

Question 53

What is hypertensive kidney disease?

Answer 53

aka renovascular hypertension, hypertensive, caused by kidney injury through atherosclerosis of renal arteries and their small branches in the kidney

found in 1 in 10 ppl with system hypertension

Question 54

What does decreased blood in kidney cause them to do?

Answer 54

causes kidney to release renin to convert plasma protein angiotensin into angiotensin I

in liver and lungs angiotensin I in converted to angiotensin II which triggers vasoconstriction and aldosterone secretion = hypertension

Question 55

s/s of hypertensive kidney disease

Answer 55

typical features of systemic hypertension:

headache, heart palpitations, tachycardia, light-headedness and anxiety, damage to retina

risk of heart failure, myocardial infarction and stroke

Question 56

how to diagnose renal hypertension?

Answer 56

pt histroy, kidney examination bc surgery may help, ultrasound, renal arteriography to view blood flow and obstruction
test blood for elevated renin to determine which kidney is affected

Question 57

What istreatment for renal hypertension?

Answer 57

surgery to correct underlying renal vascular problems, endarterectomy or angioplasty

manage symptoms with antihypertensive med and diuretics and controlling sodium intake

lower risk with regular exercise, low fat, not smoking and treating hypertension, all of which help prevent atheroscleorisis

Question 58

What is nephrotic sydnrome?

Answer 58

aka nephrosis

disease of basement membrane of glomerulus chronic disease with proteinuria, hypoalbuminemia, hyperlipidemia, and edema

results from glomerular injury in which there is increased permeability (from certain toxins, rugs, pregnancykindey transplant) from other kidney diseases (most common causes are glomerulpnephritis and diabetes)

Question 59

s/s of NS?

Answer 59

edema of the ankle and around the eyes
loses excessive amt of pritein, mainly albumin in urine (proteinuria)
pleural and genital edema
diminished glomerular filitration = sodium and water retenion = hypertension and edema
microscopic or gross hematuris
sloughed-off fat bodies
low bp
lethargy
anorexia
high lipids (can lead to premature atherosclerosis and raise risk for infection and blood clots)

Question 60

how to diagnose Nephhrotics sydrome?

Answer 60

urinalysis (for high protein levels and casts), blood tests (high lipids and low albumin), kidney biopsy (determine presence of lesions characterisitic of NS)

Question 61

How to treat NS?

Answer 61

addressing uderlying cuase

adjust dietary protein accordingingly, decreased sodium
use of ACE inhibitors

coritocsteroids, hypertension meds, diuerteics, immunosuppressants, cholesterol-lowering drugs and blood-thinning meds

Question 62

How to treat chronic kidney disease?

Answer 62

with anti-hypertensives, diuerteics and kidney dialysis

controllling wt, blood lipids, sodium intake, sugar levelsand engaging in regular exercise

renal dialysis, then kidney transplant

Question 63

What is hemodialysis?

Answer 63

blood is removed from body and passed through dialysis membrane (artificial kidney - hemodialyzer) where access to bloodstream in arm, leg, subclavian vein w/ inernal fistula alows blood to be removed from body to remove toxic substances beforereturning blood to body

3-6 hrs long in clinic

Question 64

What is peritoneal dialysis

Answer 64

dialyzing fluid is introduced into the abd cavity where the peritoneum or cavity lining acts as a dialysis filter membrane (draws toxic material out of capillaires surrounding the body cavity)

allows pt more movement and freedom bc it is collected in bag

may not work in advanced chronic kidney disease

Question 65

about __%
of live kidney recipients survive at least 5 years
after the transplant

Answer 65

90

Question 66

What is end-stage renal disease (ESRD)?

Answer 66

complete failure of kidney functioning and ends in death

after final stages of chronic kidney disease when dialysis and kidney tranplant havent succeeded

reduce risk by controlling bp, blood sugar levels, monitor total urine protein levels, reduce dietary protein, dont smoke

Question 67

What is hydronephrosis?

Answer 67

condition of urine retention within dilated kidney tubules (in 1 out of 100 ppl) bc obstruction of urinary tract won’t let it past (increases pressure)

results from urinary calculi, congenital defect, tumor, enlarged prostate gland or other obstruction of renal pelvis or ureter, enlarged uterus,

Question 67

what are hydrourethers?

Answer 67

ureters dialte above obstuction

Question 68

s/s of hydronephrosis?

Answer 68

hematuria, vague back pain, pyuria, fever if infection, diminshed urine output, fever, chills, kidney may be palpable

Question 69

how to treat and diagnose hydronephrosis?

Answer 69

diagnose - physical exam, contrast studies of ureters and kidneys, retrograde pyelography, cystoscopy to rule out an obstruction by tumor of bladder or prostate, CT or ultrasound

treat - antibiotics, analgesics, catheterization and surgery to remove obstruction

Question 70

What is chronic glomerulonephritis?

Answer 70

slow progressing inflammation of glomeruli = glomerular necrosis, chronic kideny disease and renal fialure (first is inflammation, followed by progressive desutrction of many gloumeruli)

caused by chronic kidney and glomerular diseases, systemic lupus erythematosus, renal autoimmunity, and hemolytic uremic sydrome

s/s then nephrotics sydrome then chronic kidney disease and renal failure

Question 71

How to diagnose chrnic glomerulonephritis?

Answer 71

history
urinalysis
blood urea nitrogen
ultrasonogrpahy
serum creatinine levels ultrasound & CT (small kidneys)
renal biopsy = glomerular damage
electron micorscopy and immunoflourescence

Question 72

How to treat chrnic glomerulonephritis?

Answer 72

irreversible, treat s/s (edema, hypertension) with antihypertensive med, low-sodium and low-protein diet, limited fluid intake, diuretic and dialysis or transplant, ACR inhibitors, prevent CHF and uremia

administer antihypertensives, diuretics, antibiotics if UTIs,

Question 73

What is urinary incontinece?

Answer 73

loss of bladder control

increases with age, risk factors r being female, verweight, smokigng and prostatitis

sign of underlying disease or habits

Question 74

What is temproary incontience caused by?

Answer 74

alcohol, caffeine, excess fluid intake, and medications

UTIs and constipations irritate bladder

Question 75

What is continuing urinary incontinence associated with?

Answer 75

pregnancy and childbirth, bladder inflammation, infection, cancer, kidney stones and prostatitis or prostate cancer

neurologic diseases, tumors and spinal injuries

Question 76

s/s of urinary incontinence?

Answer 76

dribbles of urine to complete loss

stress incontinence - unexpected flow of urine with coughing, sneezing, laughing or lifting (caused by weakening of pelvic floor miuscles and urethral structure, trauma from childborth, pressure from existing pregnacy, hormonal changes)

sense of urianry urgency followed by flow of urine

overflow inctinence (inabiltiy to empty bladder = continued leaking followign urination)

Question 77

how to diagnose and treat urinary incontinence?

Answer 77

diagnose - history, phyiscal exam, lab blood tests, ultrasound and cystoscopy

treat - behavioral changes, pelvic exercises, meds, catheterization surgery or other interventions

Question 78

What is renal cell carcinoma?

Answer 78

rare cancer (3% of adult cancers)

2x in men, betwen 50-60

smokers r 2x more likely

grows slowly for several yrs, painless hematuria, abd mass, flank pain (also wt loss, anemia, fever, hepatic dysfunction , hypercalcemia)

frequently spreads to lungs, liver, bones and brain

Question 79

s/s of renal cell carcinoma?

Answer 79

pain, typical signs of loss of appetiti, wt loss, anemia, elevated WBC (leukocytosis)

Question 80

What is Wilms’ Tumor?

Answer 80

aka nephroblastona

most common kidney tumor of childhood and 4th common childhood cancer

fast growing adenosarcoma that affects children younger than 10 yrs, arising from abnormal fetal kidney tissue that is left behind duing early embryonic life (metastasizes through blood and lymph vessels)

begins after child is born

abt 20% cases r hereditary

• associated w/ several congential anomalies, such as aniridia (absnece of iris) and genitourinary anomalies (cryptorchidism and ambiguous genitalia)

most tumors r unilateral but 10% r bilateral or multicentric

Question 81

s/s of wilms’ tumor?

Answer 81

mass in kidney region (firm, nontender, confined to 1 side of body) hematuria, pain in abd or chest, anemia, intestinal obstruction, contstipation, wt loss, fever vomiting and hypertension

Question 82

main influencer of wilm’s tumor?

Answer 82

The Wilms’ tumor gene (WT-1)

if gene is missing or mutated = congential defects which later becomes site of tumor

Question 83

How to diagnose and treat Wilm’s tumor?

Answer 83

diagnose - physical exam, seek associated congenital anomalies, signs of malignancy (increased size of liver and spleen and lypmhadenopathy), blood tests, abd ultrasonogrpahy, CT and ultrasound + kidney bipsy for confimration

treat - surgical removal, chemo, raidaiton therapy

Question 84

What is carcinoma of bladder?

Answer 84

malignatn tumor in urinary bladder

3% of cancer in men 1+% in women

2 1/2x more likely if smoker

Question 85

s/s of carcinoma of the bladder

Answer 85

bleeding, burning pain, crampling and inability to urinate

Question 86

how to diagnose and treat carcinoma of the bladder?

Answer 86

diagnose - physical exam, urinalysis procedures, biopsy, blood analysis, cytoscope

treatment - if urinary bladder is surgicall removed than ileal conduit may be cosntrcted to store and evacutate urine

Question 87

What is polycystic kidney disease (PKD)?

Answer 87

development of numerous fluid-filled pockets of tissue (cysts) within the kidney (bilateral)

cysts form from dilated nephrons and collecting ducts, kidneys become grossly enlarged w/ compression of surrounding tissue,

2 genetic forms (90% - autosomal dominant affects adults, autosomal recessive affects children)

Question 88

s/s PKD?

Answer 88

development of numerous fluid-filled pockets of tissue
within the kidney

may = kidney ways 20-30 lb

lumbar or abd pain and tenderness, hypertension and hematuria

Question 89

how to diagnose and treat PKD?

Answer 89

diagnose - microscopic blood, proteinuria, pus in urinalysis, radiography, abd CT, abd MRI, IVP, physical exam + renal ultrasound or CT

trat - no cure so treatment is aimed at conrtolling high bp, pain and infection, may drain srugery using surgery, need dialysis and kidney transplat eventually

Question 90

What is medullary sponge kidney?

Answer 90

named for the appearance of the inner part (medulla) of an affected kidney

affects 1 in 5,000-20,000 ppl in US

present at birth but asymptomatic until adulthood

Question 91

s/s of medullary sponge kidney?

Answer 91

recurrent kidney stones
hematuria
pain

Question 92

hgow to diagnose and treat medullary sponge kidney?

Answer 92

diagnose - ultrasound or IV pyelogram

treatment - no treatment available except increasing fluids to reduce risk of forming stones and their complicatiosn

Question 93

Congenital abnormalities of the ureters, bladder, and urethra occurr in about __% of births.

Answer 93

5

Question 94

What are some congenital ureter disorders?

Answer 94

duplication
abnormal position
abnormal location of openings, abnormal dilation
constrictions

Question 95

What are some congenital urinary bladder disorders?

Answer 95

malformed wall or pouches

Question 96

What are some congenital urethra disorders?

Answer 96

epispadias (urethral opening develops on the dorsal side
of the penis)

hypospadias (urethral opening occurs on the ventral surface of the penis)

Question 97

As much as _______% of
the nephrons may degenerate between ages 25
and 85.

Answer 97

30–40%

Question 98

What does reduction of rennin lead to?

Answer 98

reduction in aldosterone actibity = ;ack of slat and water retention = more urine released by kidney

Question 99

Why does urinary retneion occur?

Answer 99

urinary bladder loses muscle tone and cannot empty completely

obstructuon bc prostate enlargement

increases risk for UTIs

Question 100

Kidney cancer
increases significantly after ____________, and the incidence of bladder cancer increases after ___________.

Answer 100

age 60

age 70

Question 101

prognosis of Wilms tumor?

Answer 101

• has one of highest survivial rates of all childhood cancers
• low stage and favorable tumor histoloy have greater than 90% cure rate
• late stage or unfavorable histoloy has 50% cure rate
• may suffer from renal impairment, heptatoxicity, cardiotoxiciity, or second maliginancies form cancer therapy

Question 102

what is goodpasture syndrome?

Answer 102

• aka anti-glomerular basement membrane (GBM antibody disease
• presence of antibodies directed against an antigen in GBM
• antibodies cause complement-mediated tissue damage in glomerular and alveolar basement membrane = glomerulonephritis

Question 103

s/s of goodpasture syndrome?

Answer 103

• acute glomerulonephritis
• relatively acute renal failure with proteinuria
• anemia
• hemoptysis
• hematuria
• wt. loss
• fatigue
• fever

Question 104

how to diagnose and treat goodpasture syndrome/

Answer 104

diagnose - suspected in any pt w/ acute glomerulonephritis, esp if aso pulmonary hemorrhage and acute renal failure, detect anti-GBM antibodies in serum or kidney using ELISA, immunofluorescence or renal biopsy + urinalysis

treat - plasmapheresis, immunosuppressive agents (corticosteriods and cyclophosphamide) for 6-12 months w/ hemodialysis and kidney transplantation as last resorts

Question 106

s/s of acute glmerulonephritis?

Answer 106

proteinuria
edema
decreased urine volume
heatmuris (can range from insignificant to sudden onset of urin that is grossly bloody (gross hematuria)
= urine may appear dark or may be described as coffee color
= hypertension related to altered renal funciton
- fluid retention
- headaches
- visual distrurbance
- maliase
- anorexia
- low-grade fever
- flank or back pain frm swelling of kidney tissue

Question 107

s/s of CGN?

Answer 107

at first asymptomatic
- hypertension, hematuria, proteinuria, oliguria, edema, renal failure, severe hypertension, azotemia (failure to remove urea from blood), uremic frost (excrete urea through sweat glands)
- fatigue
- malaise
- N&V
- pruritus
- dyspnea

Question 108

what are the types of peritoneal dialysis?

Answer 108

• continous ambulatory peritoneal dialysis (CAPD) takes place w/o machine by allowing solution to drain by gravity into dialysis bag around waste (takes abt 15 min, repeat 3-4 times a day and once at night)
• continous cycling peritoneal dialysis (CCPD) takes place while pt sleeps w/ use of cycling machina
• intermittent peritoneal dialysis (IPD) takes several hours, performed 3-5x week in clinic

Question 109

What is continous renal replacement therapy?

Answer 109

• called hemofilitration
• performed in hosptial setting
• take place typically in ICU for pt in acute renal failure (ARF)
• takes place 12-24 hrs each day, every day

Question 110

What are some nephrotoxic agents

Answer 110

solvents: carbon tetrachloride, methanol, ethylene glycol
Heavy metals: lead, arsenic, mercury
pesticides
antibiotics: kanamycin, gentamicin, polymyxin B, amphotericin B, colistin neomycin, phenazopyridine
NSAIDs
iodinated radiographic contrast media
antineoplastic agents
misclelaneous compounds: acetaminophen, amphetamines, heroin, silicon, cyclosporine
poisonous mushrooms

Question 111

What is acute renal failure? -

Answer 111

• aka acute kidne yinjury (AKI)
• sudden and severe reduction in renal function (few days)
• common clinical emergency bc nitrgenous waste products bein accumulate in blood quickly, causing acute uremic episodes`

Question 112

s/s of AKI?

Answer 112

• oliguria
• GI disturbances
• headache
• drowsiness
• ## other alterations in level of consciousness

Question 113

What is etiology of AKI?

Answer 113

• dimiisheed blood flow to ,kidneys (circulatory shock or heart failure)
• intrarrenal damage or disease
• mechanical obstruction of urine flow
• certain antibiotics (gentamicin and streptomycin can cause AKI in pt who have predisponsing factors)

Question 114

diagnose and treat AKI?

Answer 114

diagnose - blood tests, urinalysis (oliguria and retention of nitrogenous wastes, elevated BUN, serum creatinine, potassium levels, renal ultrasonography, radiography (CT or MRI), IVP)

treat - cause,monitor and support all body systems through uremic crisis, may be evaluated for dialusis, fluid intake amd output r balanced, ensure protein is being replacedin right proportions to prevent metabolic acidosis, high carb/low protein diet, control sodium and potassium intakes, antihypertensives, diuretics, IV fluids, antiinfective agents

Question 115

s/s of CKD?

Answer 115

• weak, tird, lethargic
• hypertension and edema result from retention of fluid
• arrhythmias
• muscle weakness
• dyspnea
• metaboic acidosis
• ulceration of GI mucosa
• hair and skin changes

Question 116

diagnose and treat pyelonephritis?

Answer 116

diagnose - clinical findings, urinalysis (clean-catch urine specimen that shows increased WBCs, RBCs, presence of bacteria ,p us, protein and castes), blood caulture, radiographic studes

treat - IV or oral antibodies, increased fluid intake, bed rest, if recurrences testing (IVP, and/or renal ultrasonography), surgery to relieve an obstruction or correct anomaly

Question 117

s/s of renal calculi?

Answer 117

• large stone formed in shape of renal pelvis is known as staghorm calculus
• small stones can be passed spontaneously unnoticed
• if infection or blockage caused by calculi is present the sudden severe pain in flank area known as renal colic w/ urinary urgency
• N*V
• hematuria (causedby trauma from small stones)
• fever
• chills
• abd distention

Question 118

etiology of renal calculi?

Answer 118

• hereditary tendency for development of certain types of stones has been notes
• form when excess of calcium or uric acid
• men r more prone to kidney stones
• occurance from 30+ up to and including 50s
• calculi from when sources of crystals r found in urine along with absence of crystalline inhibitors and urine is supersaturated w/ poorly soluble

Question 119

diagnose and treat renal calculi

Answer 119

diagnose - family history, clinical findings, urinalysis, KUB radiographic studies, IV urography, renal ultrasonography, CT, strain urine to analyize stones

treat- remove calculi, treat pain and infection, resolve causative factors, analgesic, alpha-blocker (relaxes muscle of bladder, allowing stone to pass), small calculi r treated w/ observation and fluid hydration, large r removed w/ surgical procedures w/ lithotripsy, ureteroscop, electrohydraulic lithortipsy (EHL), laser lithotripsy, ureteroscope, stent in kidney pelvis to prevent edema and spasms of ureter, cystoscopy, percutaneous nephrolithotomy (small incision is made into kidney, stone is shattered by using ultrasound or EHL), diuretics

Question 120

diagnose and treat diabetic nephropathy?

Answer 120

diagnose - elevated BUN level, increase in cholesterol, urianlysis shows protein and pus in urine, urinary albumin, radiographic studies of kidneys and renal biopsy,

treat - medical control of diabetes and bp, prompt treatment of infection, ACE inhibitor for bp and prolongation of proper kidney function, balance fluid intake and ouptu, diruteics, modified low-protein and low-fat diet, dialysis or evalv for kidney transpant

Question 121

What is neurogenic bladder?

Answer 121

• dysfunction of urianry bladder that consists
• caused by insult ot brain, spinal cord, nerves supplying lower urinary tract (trauma or disease), cerebrobascular accident, spinal cord trauma

Question 122

s/s of neurogenic bladder?

Answer 122

• depends on cause of condition
• may have to surgically remove kidney if pt has intractable pain, renal stones or persistent infection
• hesitancy
• decreased volume of urinary streams
• urinary retnetion from decreased or absent stimuli (motor paralysis)

Question 123

types of neurogenic bladder?

Answer 123

• unhibited neurogenic bladder: unable to control voiding pattern and is persistently incontient of small amts of urine
• reflex neurogenic bladder: normal sensation is absent with unctrolled bladder contractions, spontaneous voiding of spurts of urine
• autonoum neurogenic bladder: all sensations and contraction capablities r abent, resulting in inability to void w/o applying pressure ot suprapubic area

Question 124

diagnose and treat neurogenic bladder>

Answer 124

diagnose - history of trauma or disease process, clinical findings, urodynamic studies that assess bladder function, urine flow rate may be evaluated by an uroflowmeter (device for continous recording of urine flow in mL per second)

treat - prevention of UTIs and attemptos t orestore some normalcy in function (means for storing urine and bladder emptying r of priamry importance), catherization, drug therapy w/ parasympathomimetic agents, surgery, external collection devices, some complications include hydronephrosis and renal failure

Question 125

how to diagnose and treat stress incontience?

Answer 125

diagnose - endoscopy, voiding cystourethrography (VCUG), reveal abn bladder position

treat - exercises (kegel exercises or pelvic floor muscle tightening), estrogen replacemnt, drug hterapy, surgical repair, ocllage injections

Question 126

diagnose and treat RCCs>

Answer 126

diagnose - radiologic exam, abd CT, abd ultrasonograpy, look for metastasis, bone scanning, biopsy or tumor resection

treat - surgical removal, partial nephrectomy, radical nephrectomy, metastatic RCC is usually resistant to surgical treatment and radiaiont or chemo, may use immunotherapy

Question 127

What is bladder tumors?

Answer 127

• usually involves transitional epithelium (urothelium) that lines the surface of bladder (also lines the entire urinary tract from renal pelvis to prostatic urethra)
• s/s r gross, intermittent, painless hematuria, pain in flank or suprapubic area, voiding symtpoms (dysruia, urgency, increased frequency), fatigue, wt loss and anorexia
• biggest cause is environemental exposures (occupational exposure to aniline dyes, diesel exhaust, cig smoking, frequent bladder infection or prior bladder cancer, HIV)

Question 128

diagnose bladder tumors?

Answer 128

diagnose - unexplained hematuria, fuull urologic evalv of entire urianry tract, cystoscopy, urinary cytology (examination of transitional cells in pt voided urine), IVP, renal ultrasonogrpahy, CT, biopsy,

Question 129

treat bladder tumors?

Answer 129

treat - tumor resection via transurethral resection of bladder tumor (TURBT) (complete cystoscopic resection of any visible tumors and selected biopsies of bladder mucosa) (up to 80% of tumors will recur within 12 months)
urine cytology and cystoscopy
bacillus Calmette-Guerin (BCG) (mycobacterium modified to less patholgoic state induces local immune reaction that suppresses tuumor growth)
radical cystectomy or partial cystectomy, adjuvant chemoradiotherpay, multidrug chemo (for metastatic)