Anxiety Flashcards

1
Q

Diagnostic Criteria for General Anxiety Disorder (GAD)

A

persistent symptoms for at least 6 months
accompanied by at least 3 psychologic or physiologic symptoms
- excessive anxiety
- worries that are difficult to control
- feeling on edge
- poor concentration
- restlessness
- fatigue
- muscle tension
- sleep disturbances
- irritability
- social / occupational impairment
- poor coping skills

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2
Q

Diagnostic Criteria for Panic Disorder

A

Series of unexpected, spontaneous attacks of intense fear
Attack followed by at least 1 month of fear of recurrence
>/= 4 symptoms during attack:
- Fear of losing control, going crazy, dying
- depersonalization
- de-realization
- abdominal distress/ nausea
- chest pain/discomfort
- chills/hot flashes
- palpitations/tachycardia
- SOB
- trembling
- sweating

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3
Q

Diagnostic Criteria for Social Anxiety Disorder (SAD)

A

duration must be at least 6 months
fears:
- judgement
- embarrassment
- humiliation

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4
Q

Diagnostic Criteria for Post Traumatic Stress Disorder (PTSD)

A

Exposure to traumatic event is required
- threatened death or serious injury
- possible harm to self or others

Patients must have at least:
- 1 intrusion symptom
- 1 avoidance symptom
- 2 negative alterations in cognition and mood
- 2 symptoms of increased arousal

Symptoms must be present > 1 month

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5
Q

Intrusion Symptoms (PTSD)

A
  • recurrent, intrusive, distressing memories of the trauma
  • recurrent, disturbing dreams of the event
  • dissociative flashbacks
  • physiologic reaction or psychological distress from reminders of trauma
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6
Q

Avoidance Symptoms (PTSD)

A
  • avoiding conversations, thoughts, or feelings about the event
  • avoiding people, places, or activities that are reminders of the event
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7
Q

Negative alterations in cognition and mood (PTSD)

A
  • inability to recall an important aspect of the trauma
  • anhedonia (lack of pleasure)
  • estrangement from others
  • restricted affect
  • negative beliefs about oneself
  • distorted beliefs about oneself
  • distorted beliefs causing one to blame others or themselves for the trauma
  • negative mood state
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8
Q

Increased Arousal Symptoms (PTSD)

A
  • decreased concentration
  • easily startled
  • hypervigilance
  • sleep disorders
  • agitation, irritability, outbursts
  • self destructive behavior
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9
Q

Diagnostic Criteria for Obsessive Compulsive Disorder (OCD)

A

obsession- persistent recurrent idea-thought-impulse that is intrusive and inappropriate and produces marked anxiety

compulsion- repetitive behavior or mental act performed in response to an obsession.

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10
Q

Common Antidepressant Side Effects

A
  • HA
  • GI upset
  • insomnia
  • sexual dysfunction
  • weight gain
  • increased anxiety (early)
  • drowsiness
  • tremor
  • increased bleed risk
  • Serotonin syndrome
  • withdrawal/ discontinuation syndrome
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11
Q

SSRI’s approved for GAD

A

Escitalopram (Lexapro)
Paroxetine (Paxil)

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12
Q

SNRI’s approved for GAD

A

Duloxetine
Venlafaxine

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13
Q

GAD nonbenzodiazepine anti-anxiety agents

A

Vortioxetine (Trintellix)
Pregabalin (Lyrica)
Quetiapine XR (Seroquel XR)

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14
Q

1st line treatment for GAD

A

SSRI:
- escitalopram
- paroxetine
- sertraline

SNRI
- duloxetine
- venlafaxine XR

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15
Q

2nd line treatment GAD

A

Buspirone
Imipramine

Antihistamines
- Hydroxyzine

Antipsychotics
- Quetiapine XR

Benzodiazepines (If no SUD)

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16
Q

NOT recommended for GAD

A

ziprasidone
propranolol
tiagabine

17
Q

Drug reserved for treatment resistant GAD

A

Bupropion XL

18
Q

Benzodiazepines used for anxiety

A

Alprazolam (Xanax)
Chlordiazepoxide (Librium)
Clonazepam (Klonopin) panic only
Clorazepate (Tranxene)
Diazepam (Valium)
Lorazepam (Ativan)

19
Q

Less lipophilic benzodiazepines

A
  • lorazepam
  • oxazepam

slower absorption / onset of action
longer duration of action

20
Q

more lipophilic benzodiazepines

A
  • diazepam
  • clorazepate

faster absorption / onset of action
shorter duration of action

21
Q

High potency benzos

A

clonazepam
alprazolam

22
Q

High lipophilicity benzos -> fast onset + euphoria

A

diazepam
clorazepate
alprazolam

23
Q

Lower lipophilicity benzos -> slower onset + less euphoria

A

lorazepam
oxazepam

24
Q

Long duration benzos

A

diazepam
chlordiazepoxide
clonazepam

25
Q

short duration benzos

A

alprazolam, lorazepam, oxazepam

26
Q

Benzodiazepine discontinuation : therapy > 8 weeks

A

taper over 2-3 weeks

27
Q

Benzodiazepine discontinuation : therapy > 6 months

A

taper over 4-8 weeks

28
Q

Benzodiazepine discontinuation : therapy > 1 year

A

taper over 2-4 months

29
Q

SSRIs approved for Panic Disorder

A

Fluoxetine (Prozac)
Paroxetine (Paxil)
Sertraline (Zoloft)

30
Q

SNRIs approved for Panic Disorder

A

Venlafaxine

31
Q

NOT recommended for panic disorder

A

Buspirone
Propranolol
Tiagabine
Trazodone

32
Q

When can benzos be used as first line for panic disorder

A

severe urgency

-> high potency (alprazolam, clonazepam) preferred but diazepam and lorazepam are possibly effective at higher doses

33
Q

SSRIs approved for SAD

A

Paroxetine (Paxil)
Sertraline (Zoloft)

34
Q

SNRIs approved for SAD

A

Venlafaxine XR

35
Q

NOT recommended for SAD

A

Buspirone
Atenolol
Imipramine
Levetiracetam
Quetiapine

36
Q

SSRIs approved for PTSD

A

Paroxetine (acute)
Sertraline (long term)

37
Q

PTSD augmentation agents for patients experiencing persistent symptoms or partial response to SSRI therapy

A

Intrusive thoughts / hypervigilance:
- risperidone
- quetiapine
- olanzapine

Nightmares
- prazosin

Anger
- lamotrigine

Sleep
- trazodone

Anxiety, sleep, nightmares
- clonidine

38
Q

SSRIs approved for OCD

A

Fluoxetine (Prozac)
Fluvoxamine (Luvox)
Paroxetine (Paxil)
Sertraline (Zoloft)