Innate Immunity Flashcards
What are defensins?
Antibacterial enzymes on the skin
What line of defense are urinary and GI tract?
First, because they flush away unwanted materials
Lyzozyme:
nonspecific bacterial enzyme in saliva and tears
Why does oral medication (antibiotics) cause Clostridium difficile or other types of diarrhea?
Damage of non-invasive bacteria that prevent other bacteria from colonizing
Events occurring during the innate response
-Threat recognition
-innate immune cell activation and complement system
-production of cytokines, chemokines, acute phase proteins and defensins
-upregulation of cell adhesion molecules
-attraction of cells to site of damage
-elimination, resolution, tissue repair
How is a threat recognized? PRR:
Pattern recognition receptors are looking for PAMP (infectious agents) or DAMP (host)
PAMP: pathogen associated molecular patterns
DAMP: damage associated molecular patterns
PRR cont.
Recognition is structurally-specific
Common to whole groups of organisms or host cells
Example: LPS: lipopolysaccharide: sound on all gram-negative bacteria
How is PRR diff from antigen receptor? nonspecific
PRR cont.
Can be intracellular, on the cell surface, or soluble/secreted
TLR: toll-like receptors (kinds of PRR)
Not expected to know these in depth, they are new to A&P, just know some are on the cell surface and others are intracellular, and they cause vasodilation, leukocyte attraction, fever (intracellular response releases interferons which interrupt viral replication)
Step 2 of innate response after binding PRR and PAMP
genes are activated that will transcribe cytokines, adhesion molecules, antimicrobial molecules
Step 3: Acute phase response
proinflammatory cytokines (like histamine, prostaglandins, etc.) act on the liver which increases 1000x secretion of acute phase proteins (a variety of proteins which have various important roles in the innate immune response)
What part of inflammation causes heat and redness?
increased blood flow to site
Five cardinal signs of inflammation:
Heat, redness, swelling, pain, loss of function (due to tissue damage)
Complement system (See white board image!)
Group of plasma proteins produced in the liver which help destroy pathogens (complement the work of antibodies)
3 complement pathways: classic, alternative, lectin
MAC (membrane attack complex)
protein complex poking a hole in gram negative bacterial membranes