Module 3: Eukaryotic Replicases

Question 1

T/F: Pol-alpha associates with a clamp

Answer 1

False: Pol-alpha does not have any association with PCNA

Question 2

What protein in the replisome greatly increases Pol-delta’s procssivity?

Answer 2

PCNA clamp

Question 3

What makes up the Pol-delta complex?

Answer 3

Pol-delta, PCNA, and RF-C

Question 4

What direction does MCM helicase track?

Answer 4

3’–> 5’ on the leading strand for synthesis

Question 5

What are some of the important partners of FEN-1 exonuclease?

Answer 5

PCNA and Dna2

Question 6

T/F: FEN-1 has helicase activity

Answer 6

False; FEN-1 only contains 5’–>3’ exonuclease activity