1.2 Development of the CNS Flashcards Preview

Yr 2 Sem 2 NSNP > 1.2 Development of the CNS > Flashcards

Flashcards in 1.2 Development of the CNS Deck (22):
1

Why is the NS the most susceptible to insult during pre-natal development?

Because it takes a long time to develop

2

What process produces the notochord?

Gastrulation

3

What is the role of the notochord?

Induces neurulation

4

What is the depressed mid-region of the neural plate called?

The neural groove

5

What produces the neural tube?

Neural folds gradually approach each other in the midline and fuse

6

What is the notochord?

Solid rod of cells running in the midline with an important signalling role

7

What does the notochord direct?

The conversion of overlying ectoderm to neurectoderm

8

By which day is the neural tube completely closed?

Day 28-32

9

How long does neurulation take?

10 days

10

What are the two openings at the cranial and caudal end of the neural tube called?

Anterior and posterior neuropore

11

What do neural tube defects result from?

Failure of the neural tube to close
Can occur caudally or cranially

12

what does a cranial neural tube defect result in?

Anencephaly

13

What does a caudal neural tube defect result in?

Spina bifida

14

Where does spina bifida occur?

Can occur anywhere along the length
Most common in lumbosacral region

15

Is spina bifida associated with cognitive delay? Why?

No
It doesn't affect the brain

16

What nearly always occurs due to spina bifida?

Hydrocephalus

17

What is anencephaly? Why does it occur?

Absence of cranial structures, including the brain
Due to failure of NT closure cranially

18

What is rachischisis?

Failure of neural fold elevation
Most severe neural tube defect
The neural tube fails to form and instead there is splayed nervous tissue across the surface of the foetal back

19

How can neural tube defects be diagnosed?

Raised maternal serum a-fetoprotein
USS

20

How can neural tube defects be prevented?

Folic acid
Preconceptually (3months) and during the first trimester

21

Why does the cauda equina form?

After the 3rd month, the vertebral column grows faster than the spinal cord
Spinal roots must elongate because they still exit at their intervertebral foramen

22

During neural fold formation, what three primary brain regions can be distinguished?

Forebrain - prosencephalon
Midbrain - mesencephalon
Hindbrain - rhombencephalon