properties of receptors

Question 1

what is pharmacodynamics

Answer 1

the pharmacology concerned with the effect of the drug and the mechanism of its action

Question 2

what is a receptor

Answer 2

a macromolecular component of a cell with which a drug interacts to produce its characteristic biological effect

Question 3

what concentrations are receptors found in and what will this show and why

Answer 3

low
it will show saturable binding with a maximum binding as there is a finite number of binding sites

Question 4

what will many drugs have for its receptor and what effect does this have

Answer 4

high affinity for it meaning the drug will bind at low concentrations

Question 5

how is affinity measured

Answer 5

the disassociation constant KD

Question 6

what doreceptors show and what effects this

Answer 6

selectivity
depends on receptor and size, shape, charge of drug

Question 7

what are drug-receptor interactions usually and what does this mean
hint- type of reaction

Answer 7

reversible
neither molecule is permanently changed

Question 8

what size are usually drugs compared to receptors

Answer 8

smaller
molecular weigh 200 vs ~250,000 for drug vs receptor

Question 9

what does the receptor binding site have to be and why

Answer 9

complementary
as only weak binding forces hold drugs

Question 10

what do agonists induce in receptors and why

Answer 10

conformational change as receptors are not rigid

Question 10

what do agonists induce in receptors and why

Answer 10

conformational change as receptors are not rigid

Question 10

what do agonists induce in receptors and why

Answer 10

conformational change as receptors are not rigid