endocrino (desde slide 39 carcinoma medular hasta el final que es paratiroides) Flashcards

1
Q

carcinoma medular

A

diferenciacion de celulas c que secretan calcitonina

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2
Q

niveles calcitonina

A

elevados

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3
Q

normalmente tienen hipo…

A

hipocalcemia

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4
Q

mientras mayores sean los niveles de calcitonina,

A

mayor es la carga tuoral

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5
Q

metastasis en

A

cadena d elos linfonodos cervicales

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6
Q

morfo microscopica

A

puede haber depositos de amieloide

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7
Q

morfo macro

A

masa solida amarillenta parda

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8
Q

es muy agresivo y la sobrevida es:

A

sin metastasis 100% a 10 años, con metastasis a los linfonodos cervicales 70-80%, con metastasis a distancia 40-50%

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9
Q

cuales tienen mejor pronostico? los de origen familiar o esporadico?

A

los familiares, sexo fem y x joven

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10
Q

asociados a mutaciones del:

A

protooncogen RET

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11
Q

MEN2B es mas…

A

es mas grave, tienen un curso mas agresivo que los MEN2A

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12
Q

carcinoma anaplastico

A

muy indiferenciado, extremadamente agresivo (de compromiso extratiroideo)

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13
Q

tumor de gente mayor

A

carcinoma anaplastico

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14
Q

clinica del carciona anaplasico

A

crecimiento rapido, signos locales como estridor, disfagia, dolor, disnea,

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15
Q

macro de carciona anaplasico

A

turmo grande, mal delimitado, compromete tejidos blandos paratiroideos, focos de hemorragia y necrosis

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16
Q

paratirides no neoplasica

A

hiperplasia 15% de todos los hiperparatioiridsmos, l mayoria son mujeres

17
Q

macro paratiroides no neoplasica

A

asimetrico, no afecta a todas las glandulas x igual

18
Q

adenoma paratioides

A

benigno, 85% d elos casos de hiperparatoiroidemismo, afecta gmnete a una glandula, sintomas clinicos dados por hipercalcemia por hiperparatiroideismo,

19
Q

carcinoma paratioideo

A

tumor maligno raro

20
Q

carcinoma paratioidismo clinca

A

elevados los niveles de calcemia y paratohormona

21
Q

clave para diferecniar adenoma de carcinoma

A

carcinoma tiene presencia de invasion linfovascular, perineural o a tejidos blandos peritumorales

22
Q

causa d emuerte de carcinoma paratioides

A

hipercalcemia