Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

443-SRH and MSK > midterm questions > Flashcards

midterm questions Flashcards

1
Q

what is Yohimbine used for?

A

erectile dysfunction- psychogenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

yohimbine MOA

A

alpha 2 antagonist that acts at brain center to control libido and penile erection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

which medication for ED causes penile fibrosis and potential hepatotoxicity

A

papaverine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what are some RF for priapism? what drug do these factors cause a contraindication for?

A

RF: sick cell anemia, MM, leukemia, anatomical deformity of penis
causes contraindication for alprostadil (PGE1) injection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

PGE1 MOA

A

increases AC = more cAMP and causes smooth muscle relaxation, vasoocclusion, and erection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

which 2 ED drugs should not be taken with food

A

sildenafil, vardenafil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

butea superba MOA

A

corpus cavernosum relaxation for ED- not recommended rn

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

how is L arginine used in ED

A

used with PDE5i if pt is resistant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is the most common intracavernosal sympathomimetic for priapism

A

phenylephrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what oral sympathomimetics can be used for priapism

A

terbutaline, pseudoephedrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what are the conditions for a menopause diagnosis

A

12mths with no period + elevated FSH =>30mIU/ml

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

when are VMS of menopause most intense?
1. early evening
2. early morning
3. late evening
4. during sleep

A

1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what causes the change in vaginal pH from acidic to basic in menopause

A

decreased glycogen production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

which of the following sx are more common in perimenopause than menopause
1. muscle/ joint pains
2. breast tenderness
3. headaches/ migraines
4. heart palpitations
5. low libido
6. dry skin or eyes
7. hair changes

select all that apply

A

2,3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

how long does it take for isoflavones to work for menopausal sx

A

8-12wks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

why is P used with E in MHT

A

endometrial protection from endometrial cancers caused by systemic estrogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

describe an EPT cyclic regimen

A

estrogeh continuous, progestogen for 12-14 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what were the results of the womens health initiative RCT, EPT arm

A

increase in VTE (only sig result), stroke, CHD, breast cancer
decrease in hip fractures, CRC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what were the results of the womens health initiative RCT, ET arm

A

increase in VTE and stroke
decrease in hip fractures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

what hormones were used int eh women’s health initiative RCT

A

medroxyprogesterone and CEE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

what kind of estrogen in MHT can lower VTE risk

A

transdermal- but may just be due to lower systemic dose

22
Q

what is considered strong family hx as a CI for MHT

A

2 or more first degree relatives prior to menopause

23
Q

oral ET have a high first pass effect, resulting in increased

A

TG, SHBG, TBG, CRP

24
Q

oral ET effect on lipids
1. increased HDL, lowered LDL
2. lowered HDL, lowered LDL
3. increased HDL, increased LDL
4. lowered HDL, increased LDL

A

1

25
Q

when should you choose transdermal RT over oral

A

smoker, high TG, HPTN, low libido, VTE/ CVD, gallbladder disease
shift worker, migraines, malabsorption issues

26
Q

0.625mg CEE = ___ 17b estradiol

A

1mg

27
Q

0.625mg CEE = ___ patch

A

50ug

28
Q

0.625mg CEE = ___ estrogel

A

1-2 pumps

29
Q

0.625mg CEE = ___ EE

A

5ug

30
Q

when is BTB normal with MHT? when should we investigate further?

A

normal 6-9mths, investigate if >12mthswhat is tibolone

31
Q

what is tibolone

A

a STEAR

32
Q

what is bazedosifen

A

a SERM with antagonistic ER effects on uterus and breast, agonist eff on bones

33
Q

what is duavive

A

bazedoxifen + CE

34
Q

4 nonhormonal rx meds for menopause? what do they do and how long does it take to kick in?

A

SSRI/SNRI = mood
oxybutynin = GSM
clonidine (meh)
gabapentin/ pregabalin = sleep

2-4wks

35
Q

what is ospemaifene used for

A

oral SERM for vaginal dryness

36
Q

CA-125 may be a lab test for

A

endo, but more specific for ovarian cancers- specificity may be increased if endo on ovaries

37
Q

what is dienogest used for

A

management of pelvic pain for endo- as effective as leuprolide
is a progestin

38
Q

what is danazol used for

A

endometriosis- an androgen that suppresses FSH/LH

39
Q

what is the only nonreversible AE of danazol

A

lowering of voice

40
Q

what are the 2 CI for danazol

A

severe liver disease, hyperlipidemia

41
Q

what shoudl be monitored in danazol use

A

LFTs if using for >6mths

42
Q

how long does it take buserelin to work

A

4-8wks

43
Q

what is elagolis

A

a direct antagonist for GnRH used in endometriosis

44
Q

when is add back therapy required for orilissa/ elagolis

A

> 200mg BID

45
Q

what is LUNA

A

laparoscopic uterine nerve ablation

46
Q

first line therapy for endo

A

CHC+ NSAIDs
progestins

47
Q

2nd line therapy for endo

A

LNG_IUS or GnRH agonist/ antagonist + add back

48
Q

third lien tx for endo

A

laparoscopy

49
Q

what are some “other” options for endo

A

TCAs, SNRIs, gabapentinoids, muscle relaxants
trial 2-3mths

50
Q

which endo tx are most associated with BTB

A

POP, danazol

51
Q

which 3 endo tx are best for pain

A

POP, danazol, GnRH agonists

443-SRH and MSK (24 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions