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eukaryotic pathogens > Blastomyces > Flashcards

Blastomyces Flashcards

1
Q

How do you find candidate factors?

A

mix antigens with patient serum that contains antibodies

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2
Q

What does BAD1 stand for?

A

Blastomyces ADhesion 1

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3
Q

What do BAD1 do?

A
  • adhere to macrophage
  • DOWN TNFalpha (proinflam) via secreted BAD1
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4
Q

What does DRK1 stand for?

A

Dimorphic Regulating Kinase 1

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5
Q

What do DRK1 do?

A

turns on BAD1 and allows blasto to turn into yeast

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6
Q

How did they find DRK1?

A

looked for mutants that don’t express BAD1 but still grow

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eukaryotic pathogens (15 decks)

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