Nucleophiles and solvents Flashcards
1
Q
OH-
A
strong nucleophile and base
2
Q
R-O- (not bulky)
A
strong nucleophile and base
3
Q
R2N- (not bulky)
A
strong nucleophile and base
4
Q
KOt-Bu
A
weak nuc, strong base
5
Q
LDA
A
weak nuc, strong base
6
Q
R-NH2 (amines)
A
strong nuc, weak base
7
Q
R-S-
A
strong nuc, weak base
8
Q
CN-
A
strong nuc, weak base
9
Q
N3-
A
strong nuc, weak base
10
Q
I-
A
strong nuc, weak base
11
Q
H2S
A
strong nuc, weak base
12
Q
R-SH
A
strong nuc, weak base
13
Q
H2O
A
weak/weak
14
Q
R-OH (alcohols)
A
weak/weak
15
Q
Common polar aprotic solvents
A
Acetone, DMF (dimethylfluoride), acetonitrile, DMSO (dimethylsulfoxide), ethyl acetate, THF, crown ethers, HMF
