Connective tissue Flashcards

1
Q

what sort of cells are these and how do you know

A

fibroblasts, spindle shaped nucleus

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2
Q

what do fibroblasts do?

A

secrete collagen into the ECM, most common cells in connective tissue

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3
Q

what sort of cell is this. Why? What does it do? WHen is it viible

A

macrophage. kidney shaped nucleus, phagocytoses dead cells, pathogens etc, only visible when doing phaogocytic activity

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4
Q

describe mast cells

A

large cells with spherical nucleus. Loads of granules of histamine and heparin (basophilic granules)

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5
Q

where would you not find mast cells

A

spinal cord and brain

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6
Q

what are these cells?

A

mast cells

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7
Q

what are the 3 types of fibres in connective tissue

A

collagenous, reticular, elastic

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8
Q

describe collagen/reticular/elastic fibres

A

C: thick, high tensile strength, most abundant
R: very thin collagenous fibres, network/meshlike, highly branched
E: Bundles of microfibrils embedded in elastin.

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9
Q

what is granulation tissue

A

new connective tissue and microscopic blood vessels that form on the surfaces of a wound during the healing proces

type 3 collagen

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10
Q

where do you find type 4 collagen

A

only in basement membrane

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11
Q

where do you find type 1 collagen

A

bones, skin, tendons, mature scars, cornea teeth

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12
Q

where do you find type 2 collagen

A

cartilage, nucleus pulposus, vitreous humour (eye gel)

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13
Q

where do you find type 3 collagen

A

granulation tissue, uterus, blood vessels

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14
Q

what is Haematopoiesis

A

formation of blood cells

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15
Q

what type of collagen is in reticular fibres

A

type 3

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16
Q

why are reticular fibres loose?

A

allow cells and fluid to pass through

17
Q

which stain is good for reticular fibres?

A

PAS because they are quite carby. Invisible with H&E

18
Q

what do you see here

A

reticular fibres.

19
Q

what is this

A

elastic fibres

20
Q

name a good dye for staining elastic fibres

A

orcein

21
Q

where would you find lots of elastic fibres?

A

Ligaments of the vertebral column or laminae in the aorta wall

22
Q

name some differences between proteoglycans and GAGs

A
23
Q

What is ground substance

A

an aqueous gel found in connective tissue. Contains water, GAGs, proteoglycans and glycoproteins

24
Q

which GAGs are in ground sibstance

A

hyaluronic acid, chondroitin sulphate, keratin sulphate

25
Q

describe this picture

A

loose connective tissue. Sparse cells and fibres, more ground substance

26
Q

describe this picture

A

dense connective tissue, more cells, more fibres, less ground substance