Amphetamine-like indirect sympathomimetics Flashcards

1
Q

What is the MOA of Amphetamine-like indirect sympathomimetic drugs?

A

MOA: Displaces stored catecholamines
affects NE release and reuptake
– Uptake via NET and VMAT à displaces NE in vesicles à NE release*

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2
Q

What is the Clinical Use of Amphetamine-like indirect sympathomimetic drugs?

A

– Hypotension
– Nasal decongestants (Vasoconstriction in nasal mucosa)
– CNS effects

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3
Q

What is the adverse effects of Amphetamine-like indirect sympathomimetic drugs?

A

Cardiovascular: (increased BP, increased HR, cardiac arrhythmias)
CNS (paranoia, insomnia, headaches, nervousness)

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