Beta Oxidation (Kelley Notes) Flashcards
What are the 4 steps of Beta Oxidation?
1.) Dehydration
2.) Hydration
3.) Dehydration
4.) Clevage
What is one of the primary 16-carbon fat chains?
Palmitate
Once FFA’s are inside the cell plasma membrane, what enzyme acts on it to keep it inside to begin step 1 of Beta Oxidation?
Fatty Acyl CoA Synthetase
What is the primary byproduct of Fatty Acyl CoA Synthetase on FFA’s?
A CoA is added to make:
Fatty Acyl CoA
This keeps the FFA from leaving the cell.
What energy source is used & what are its byproducts in the process of adding a “CoA” to FFA’s?
Energy Source: ATP
Byproducts: ADP + P
What molecule, secreted from an embedded transporter in the mitochondrial membrane, is added to Fatty Acyl CoA to transport it into the mitochondria?
Carnitine
In the 1st step of Beta Oxidation, Fatty Acyl CoA is converted into what?
Enoyl CoA
What is the enzyme that catalyzes Fatty Acyl CoA into Enoyl CoA?
Acyl CoA Dehydrogenase
What cofactors are associated with the 1st step of Beta Oxidation?
FAD > FADH2
Which enzyme is the rate-limiting enzyme of Beta Oxidation?
Acyl CoA Dehydrogenase
Step 1 (need it to start)
In the 2nd step of Beta Oxidation, Enoyl CoA is converted into what?
Beta-HydroxyAcyl CoA
What is the enzyme that catalyzes Enoyl CoA into Beta-HydroxyAcyl CoA?
Enoyl CoA Hydratase
What cofactors are associated with step 2 of Beta Oxidation?
H20 (Hydration Step)
In the 3rd step of Beta Oxidation, Beta-HydroxyAcyl CoA is converted into what?
Beta-KetoAcyl CoA
What is the enzyme that catalyzes Beta-HydroxyAcyl CoA into Beta-KetoAcyl CoA?
Beta-KetoAcyl CoA Dehydrogenase
What cofactors are associated with step 3 of Beta Oxidation?
NAD > NADH
In the 4th step of Beta Oxidation Beta-KetoAcyl CoA is converted into what?
Acetyl CoA
What is the enzyme that converts Beta-KetoAcyl CoA into Acetyl CoA?
Thiolase
