Other viruses

Question 1

Name three diseases caused by Pox viruses.

Answer 1

• Small pox: skin macules
• Orf virus: pain free nodule w/ gelatinous appearance
• Molluscum contagiosum: minor warty lump on skin

Question 2

Name 3 viruses that cause upper respiratory tract disease.

Answer 2

• respiratory synctial viruse: URT infections
• parainfluenza virus: URT infections
• Rubella: mild URT
• human metapheumovirus: mild URT

Question 3

Which diseases are caused by Parvo B19?

Answer 3

• Erythema infectiosum (fifth disease of slapped cheek) in children
• Arthopathy in adults
• Aplastic crisis in immunocomprimised patients
• Hydrops foetalis in babies

Question 4

Which Adenoviruses cause gastroenteritis?

Answer 4

serotype 40 & 41 adenovirus

Question 5

Name 3 virus types that cause gastroenteritis.

Answer 5

• Astrovirus (class 4)
• Norovirus (Class 4)
• Enterovirus (class 4) part of picornaviridae

Question 6

Describe the life cycle of Rotavirus (class 3 - Reoviridae). 8 steps

Answer 6

1. attachment to specific receptors
2. Entry by endocytosis
3. Virus partially uncoated: Outer capsosmere layer removed
4. activates transcriptional enz in subviral particle containing dsRNA
5. mRNA copied from neg strand of dsRNA w/in core
6. mRNA move from core -> translated by host ribosomes = capsid protein
7. Assembly: pos sense RNA enclosed in 2x layer capsid
   8 Released by cell lysis

Question 7

a) what the term “arvo virus” refers to
b) Name 2-3 virus families that are arboviruses.

Answer 7

a) refers to viruses that are transmitted by arthropods (e.g. mosquitoes)
b) Flavivirus, Alphavirus, Bunya

Question 8

What are the family and genus of Hepatitis C virus? And transmission

Answer 8

F: Flaviviridae
G: Hepacivirus
Transmission: blood-blood

Question 9

Which viruses produce syncytia and How are Syncytia produced?

Answer 9

Paramyxoviruses
1. viral fusion proteins incorporated in cell membrane
2. => fusion of membranes from neighbouring cells
3. Excess capsid protein accumulates in cell = inclusion bodies

Question 10

Class 5 group of viruses. Name 3, 2 viruses and associated diseases w/ single & multiple segmented genome

Answer 10

Single:
- Rhabdoviridae = Rabies
- Paramyxoviridae = mumps, measles
- Filoviridae = Ebola, Marburg
Segmented:
- Arenaviridae = Lassa fever
- Orthomyxoviridae = influenza virus

Question 11

Why is the use of post exposure prophylaxis vaccine for Rabies successful?

Answer 11

bc virus takes 3-12wks to get to the brain