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MWU Pharmacology I > NSAIDs > Flashcards

NSAIDs Flashcards

1
Q

Aspirin: Mechanism and Toxicity

blood brain barrier? Dosage

A

Mechanism: IRREVERSIBLE inhibition of COX-1 and COX-2

Toxicity: GI, Hepatic, Hypersensitivity, Reyes Syndrome, Salicylism

*Crosses Blood Brain Barrier

Dosage: 4 grams daily but 2 in alcoholics

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2
Q

Diflusinal

A

Mechanism: REVERSIBLE inhibiton of COX-1 and COX -2

Toxicity: GI (mild), headache, renal, hypersensitivity

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3
Q

Indomethicin: Mechanism, Toxicity, Clinical Use

A

Mechanism: REVERSIBLE Inhibition of COX-1 and COX-2

Toxicity: GI, Prolong gestation, Renal
CNS: Headache and aggravate depression

Use: RA, Not for Juvenile RA, Osteoarthritis, Tocolytic agent (Drugs that prevent preterm labor and immature birth by suppressing uterine contractions)

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4
Q

Etodolac: Mechanism and Toxicity

A

Mechanism: REVERSIBLE Inhibition of COX-1 and COX-2 (MORE COX-2 selectivity)

Toxicity: GI - less severe than Indomethacin

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5
Q

Diclofenac: Mechanism and Toxicity

A

Mech: REVERSIBLE Inhibition of COX-1 and COX-2

Tox: GI
CNS: dizziness and headache

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6
Q

Toimetin: Mechanism and toxicity

A

Mech: REVERSIBLE inhibition of COX-1 and COX-2

Tox: GI
CNS: Headache
- Caution: Anaphylactoid reactions!!!

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7
Q

Ketorolac: Mech and Tox

A

Mech: REVERSIBLE Inhibition of COX-1 and COX-2

Tox: GI
CNS: headache

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8
Q

Ibuprofen

A

Mech: REVERSIBLE inhibition of COX-1 and COX-2

Tox: Less GI than aspirin or indomethacin
Ocular disturbances
Hypersensitivity: rash / dermatitis
Avoid during pregnancy or breast feeding

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9
Q

Naproxen

A

Mech: Reversible inhibition of COX-1 and COX-2

Tox: GI less than indomethacin
CNS: headache < indomethacin
Hypersensitivity

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10
Q

Ketoprofen

A

Mech: REVERSIBLE inhibition of COX 1 and 2

Tox: GI 30%
CNS: headache

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11
Q

Oxaprozin

A

Mech: COX 1 and 2 inhibitor (once daily)

Tox: GI

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12
Q

Piroxican

A

Mech: REVERSIBLE inhibition of COX-1 and 2

Tox: GI

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13
Q

Meloxicam

A

Mech: Inhibits COX-1 and 2 but more COX-2

Tox: GI

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14
Q

Nabumetone

A

Mech: COX 1 and 2 but more COX-2

Tox: GI
CNS: headache

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15
Q

What to give for acetaminophen overdose

A

N-acetylcysteine

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16
Q

Celecoxib

A

Inhibition of COX-2

Tox: Minor disturbances: GI, CNS, respiratory, rash, sulfonamide allergy

17
Q

Acetaminophen

A

Mech: Analgesia by elevation of pain threshold probably by weak inhibition of COX 1 and COX 2

Antipyresis by action on hypothalamic heat-regulating center

Tox: Minor hypersensitivity rare
Potential hepatotoxicity and nephrotoxicity

18
Q

What to give to close patent ductus arteriosis

A

Ibprufen or Indamethacin

MWU Pharmacology I (9 decks)

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