121514 hypercoagulable

Question 1

hemophilia

Answer 1

factor deficiency of 8,9,or 11

Question 2

hemophilia A

Answer 2

factor 8 deficiency

Question 3

lab eval of hemophilia A and B

Answer 3

prolonged PTT (corrects on 1:1 mix)

Question 4

TT

Answer 4

thrombin time (you add thrombin to blood and see when it clots)

Question 5

fxns of vWF

Answer 5

support platelet adhesion

carrier for factor 8

Question 6

tx for von Willdbrand’s disease

Answer 6

desmopressin (DDAVP)–promotes vWF release from stores in endothelium

Question 7

vit K dependent factors

Answer 7

2,7,9,10, protein C, protein S

Question 8

what causes vit K deficiency?

Answer 8

drugs (warfarin, antibiotics)
malabsorption or dietary deficiency
liver disease
newborns

Question 9

liver disease results in deficiency of what coagulation factors

Answer 9

procoagulants: 2,7,9,10, 5
anticoagulants: antithrombin, protein C, protein S

Question 10

liver disease results in deficiencies in what?

Answer 10

multiple coag factors

thrombocytopenia (hypersplenism with clearance of platelets, decreased thrombopoietin production)