Antimicrobial Stewardship & Infection Control

Question 1

• Expected characteristic of the bacterial species
• Example: Escherichia coli are intrinsically resistant to macrolide drugs

Answer 1

Intrinsic resistance

Question 2

• Resistance not normally expected
• Genetic mutations
• Horizontal gene transfer

Answer 2

Acquired resistance

Question 3

Mechanisms of antibiotic resistance (AMR)

Answer 3

• Prevent the antibiotic from reaching its target at a sufficient concentration
• Modify or bypass the target of the antibiotic

Question 4

What should be considerations when a good antimicrobial steward prescribes an antimicrobial drug?

Answer 4

• Drug dosage
• Drug class and site of action
• Duration of therapy

Question 5

What organism is tracked by the OSU-CVM Antimicrobial Stewardship Program (ASP) using active environmental surveillance?

Answer 5

Methicillin-resistant Staphylococcus aureus