Unit 1 - Topic 2 - Proteins - Section C - Protein structure, ligand binding and conformational change - Part III - Reversible binding of phosphate and the control of conformation

Question 1

What does the addition or removal of a phosphate cause and what is it a common form of

Answer 1

Reversible conformational change in proteins. This is a common form of post-translational modification

Question 2

What catalyses the transfer of a phosphate group to other proteins

Answer 2

Protein kinases

Question 3

Where is the terminal phosphate of ATP transferred to

Answer 3

Specific R Groups

Question 4

What does protein phosphatases catalyse

Answer 4

Reverse reaction

Question 5

What does phosphorylation bring about

Answer 5

The conformational changes, which can affect a protein’s activity

Question 6

The activity of many cellular proteins such as what is regulated in this way

Answer 6

enzymes and receptors

Question 7

Some proteins are activated by phosphorylation while others are inhibited how is this done

Answer 7

Adding a phosphate group adds negative charges. Ionic interactions in the unphosphorylated protein can be disrupted and new ones created.