Rabbits Flashcards

1
Q

Describe rabbit diet

A

Strict herbivores that eat mostly in morning and evening (crepuscular), have high water intake and high fiber requirements. Diet should be majority high quality hay (timothy, orchard grass), plus some greens and limited pellets/treats. Cruciferous vegetables should be given in moderation due to gas. Avoid goitrogenic plants and plants with oxalic acid (spinach, swiss chard, beets, parsley), and foods high in sugar or starch.

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2
Q

What are normal rabbit behaviors?

A

Digging/burrowing, grooming ~16% of the day. Can be litterbox trained. Daily enrichment and exercise is required along with rabbit-proof environment.

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3
Q

What are considerations for rabbit housing?

A

House away from guinea pigs due to bordetella risk. Provide thick substrate on the bottom of the cage, provide a hiding spot. If housed outside, use caution to avoid diseases + parasites.

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4
Q

What is the average rabbit lifespan?

A

8-10 years

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5
Q

Describe rabbit dentition

A

Second pair of maxillary incisors called “peg teeth”, have more premolars than molars, have no tooth roots, mandible is narrower than maxilla, have mild lingual points on mandible cheek teeth, buccal points on maxilla cheek teeth

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6
Q

Describe rabbit skin and musculoskeletal systems

A

Delicate skin, molt twice a year, no footpads (don’t shave feet- leads to pododermatitis), no sweat glands. Intact females have dewlap. Skeleton is lightweight and muscle predisposes to vertebral injury. Spinal cord terminates in sacral vertebrae.

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7
Q

Describe rabbit digestive system

A

Tongue has a central lingual prominence. They are hindgut fermenters with strong lower esophageal sphincter (CAN’T vomit). Stomach is very acidic and have large amount of GALT. Saccullus rotubdus is lymphoid structure at the end of ileum that increases in size with infection or lymphoma. Have a large cecum with vermiform appendix at the end. Fusus coli is a pacemaker that controls fecal pellets, separates proximal and distal colon. Selectively retain highly digestible fibers. 2 fecal types- hard pellets and cecotrophs for re-ingesting (provide vitamin B and amino acids, passed in morning at at night, covered in mucus to survive stomach acid)

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8
Q

Describe the rabbit cardiovascular system

A

Have a small heart with left and right cranial vena cava and large coronary sinus.
Tricuspid vale is actually bicuspid. Have limited collateral circulation which can lead to ischemic damage.

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9
Q

Describe the rabbit respiratory system

A

Obligate nasal breathers (epiglottis dorsal to soft palate), no lobules in lungs, thymus persists throughout life.

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10
Q

Describe the rabbit urinary system

A

Calcium absorption INdependent of vitamin D (urinary excretion of Ca is high and can lead to stones). No carbonic anhydrase in kidney so less able to deal with high acid. Female urethra is within vaginal vestibule, NOT external

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11
Q

Describe the rabbit reproductive system

A

Females have no uterine body, have a duplex uterus and 2 cervices and are induced ovulators. Male have no os penis and open inguinal canals (testes can retract)

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12
Q

Describe the rabbit ocular system

A

Have a blind spot under their mouth, large orbital venous plexus (makes enucleation risky). Lacrimal puncta narrows along maxillary incisors; if teeth are diseased they can cause excessive tearing.

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13
Q

Describe rabbit ears

A

Pinnae are used for thermoregulation, only have vertical ear canal. Limited collateral circulation so can have necrosis. Vein is marginal, artery is central.

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14
Q

Describe venipuncture in rabbits

A

Use lateral saphenous vein, jugular, marginal ear bein, cephalic, or medial saphenous. Develop hematomas easily and blood clots quickly. 1% body weight can be taken.

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15
Q

What are the differences between rabbit blood and other mammal blood?

A

Have more biliverdin than bilirubin; have heterophils instead of neutrophils (causes caseous pus); normal for them to have lots of reticulocytes and higher total calcium concentrations. Inflammation is commonly seen as a high H:L ratio, poikilocytosis, hypercholesterolemia, increased fibrinogen, and thrombocytosis. Uncommon to see leukocytosis, left shift, or toxicity.

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16
Q

What blood values bear poor prognoses

A

Hyperglycemia (severe= GI obstruction), hyponatremia, elevated BUN

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17
Q

What PE finding carries a poor prognosis?

A

Hypothermia

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18
Q

How is a rabbit neuro exam different from other species?

A

Menace response, consensual PLR, postural reactions, and cutaneous trunci are unreliable

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19
Q

Do you fast rabbits before anesthesia?

A

No- they can’t vomit + GI stasis is very important for them

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20
Q

Where would you place an IV in a rabbit? What would you use for pre-med?

A

Cephalic, lateral saphenous, maybe marginal ear vein (necrosis/hematoma risk high), IO if necessary. Pre-med with midazolam, butorphanol, or ketamine

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21
Q

Why is intubation so difficult in rabbits?

A

Due to their dorsally placed epiglottis, small mouth, laryngospasms, and abundant soft tissue in cheeks

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22
Q

What are the risks of anesthesia in rabbits?

A

Hypotension (have atropinesterases so use glycopyrrolate), hypothermia, pain

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23
Q

What are causes of GI problems in rabbits?

A

Inappropriate diet, dysbiosis, gastritis/enteritis, obstruction, ileus

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24
Q

Describe obstruction in rabbits

A

Caused by fibrous material, foreign body, neoplasia, etc. Display acute, distended stomach/intestines, decreased gut sounds, +/- hypothermia, hypotension, brady/tachycardia, hyperglycemia may occur (>350), azotemia may occur. May have partial response to medical treatment, complete response requires orogastric decompression, gastrotomy, or enterotomy

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25
Q

Describe ileus in rabbits

A

Display gradual, decreased stomach fill, decreased feces in colon, gas, decreased gut sounds. Will see food material in stomach and gas in cecum/LI. Treat with fluids, analgesics (meloxicam, opioids, lidocaine), critical care feeding, treat underlying problem.

26
Q

What are extra-GI differentials for anorexia in rabbits?

A

Stress, organ dysfunction, dental disease, pain

27
Q

Identify a rabbit with liver lobe torsion

A

Non-specific clinical signs, diagnostics show elevated hepatocellular liver enzymes, anemia. Usually the caudate or right lobe. Diagnose with U/S, rads, or CT. Treat with liver lobectomy, medical management +/- blood transfusion.

28
Q

What are the concerns for a rabbit with diarrhea?

A

Make sure actually diarrhea not cecotrophs! Concern for enterotoxemia (dysbiosis, clostridial toxins from C. spiriforme) which is life-threatening. Most common in young rabbits because gastric pH is high and therefore more susceptible to GI disease.

29
Q

Describe mucoid enteropathy in rabbits

A

Occurs in young rabbits and commercial rabbits. Non-specific signs but show mucoid contents in LI. Etiology unknown- could be low fiber high carb diet?

30
Q

Describe Tyzzer’s disease in rabbits

A

Caused by C. piliforme, causes diarrhea, depression, and mortality in young rabbits. Can cause necrotizing colitis and myocardial necrosis.

31
Q

Describe coccidia in rabbits

A

Eimeria most common, can be intestinal (young rabbit w/ diarrhea), or hepatic (leads to abscesses and can be fatal)

32
Q

Describe OVH in rabbits- why might you perform it?

A

Need to consider fat in mesometrium, presence of second cervix, and delicacy of tissue. Ideally perform by 2 years old, otherwise can remove cervix as well if older. Indicated with uterine adenocarcinoma, endometrial hyperplasia, hydrometra, or endometrial venous aneurysm.

33
Q

Describe uterine adenocarcinoma

A

Common slow growing neoplasia. Metastasizes to lungs, liver, brain, and bones. Clinical signs include anorexia, hematuria, and respiratory signs. Diagnose with palpation, rads, +/- U/S. Treat with OVH and repeat rads afterwards.

34
Q

What are differentials for respiratory distress in a rabbit?

A

Rhinitis, pneumonia, thymoma

35
Q

What are causes of rhinitis in rabbits?

A

Pasturella multocida (ubiquitous- pathogenicity based on strain), pseudomonas, staphylococcus, bordetella, E. coli

36
Q

What does the progression of rhinitis in rabbits look like? What’s the prognosis?

A

Rhinoliths -> atrophic rhinitis -> pulmonary abscess -> otitis media/interna -> encephalitis
Diagnose with deep nasal culture, rads, CT, systemic workup. Treat with long-term antimicrobials, anti-inflammatories, rhinotomy/rhinostomy. Long term prognosis is poor.

37
Q

Describe thymoma in rabbits

A

Thymus can develop lymphoma, carcinoma, or abscess. May see decreased thoracic compliance, tachypnea, and bulging eyes. Diagnose with rads, CT, U/S, or FNA. Can treat with radiation or medical (steroids + fluids), surgery is not recommended.

38
Q

What drugs are contraindicated in rabbits?

A

P- penicillin
L- lincomycin
A- ampicillin/amoxicillin
C- cephalosporins
E- erythromycin

39
Q

What are the common types of urinary stones in rabbits?

A

Calcium carbonate, ammonium magnesium phosphate, +/- sludge

40
Q

What are proposed etiologies for urinary stones in rabbits?

A

Unique calcium metabolism, lack of exercise, incomplete voiding, infection, concentrated urine

41
Q

How would you diagnose uroliths in rabbits?

A

U/A, rads and/or ultrasound, +/- culture

42
Q

How would you treat uroliths in rabbits?

A

Surgery, fluid therapy + urohydropropulsion (note- no dissolution)

43
Q

Describe pododermatitis in rabbits

A

Common, predisposing factors include clipping the fur of their feet, obesity, arthritis, bedding type, lack of space, and Rex rabbits. Can lead to luxation of flexor tendons, secondary infections, and osteomyelitis. Treat preventatively and by managing the wound (analgesics + abx if severe)

44
Q

Describe Psoroptes cuniculi in rabbits

A

Ear mite causing ulcerative and proliferative dermatitis due to hypersensitivity reaction. Can survive off the host, highly contagious, do not remove crusts. Treat with ivermectin, selamectin, moxidectin, or fluralaner

45
Q

Describe Cheyletiella parasitovorax

A

Walking dandruff- Can cause pruritus, eggs and females can survive off the host, severe infections are seen in immunocompromised rabbits, zoonotic

46
Q

Describe fleas on rabbits

A

Cat/dog fleas, cause patchy alopecia, pruritis, erythema, sometimes anemia. Increases risk of infectious disease (myxomatosis). Treat with permethrin or selamectin (applied weekly)

47
Q

What preventative is toxic to rabbits?

A

Fipronil- Frontline

48
Q

What is the primary myiasis of rabbits?

A

Cuterebra- burrow into tissue, cause inflammation at aberrant sites w/ swelling and a breathing hole. Remove surgically

49
Q

What is the secondary myiasis of rabbits?

A

Blowflies- typically occur with underlying disease, in wounds, urine/feces staining, or dermatitis. Treat by removing larvae and doing local and systemic treatment

50
Q

Describe sebaceous adenitis in rabbits

A

Autoimmune (T cell) destruction of sebaceous glands and hair follicles. Linked to underlying disease (thymoma). Causes exfoliative dermatitis with alopecia (non-pruritic). Treat with retinoids, cyclosporine, or miglyol

51
Q

Describe otitis (externa/media/interna) in rabbits

A

Common in lop-eared breeds. Can be caused by respiratory infection or hematogenous spread. Interna is associated with vestibular signs. Diagnose with CT scan or culture (anaerobic + aerobic). Long term prognosis is poor, requires long-term antimicrobials (fluoroquinolones, azithromycin), otoscopy, and flushing (can worsen signs initially). Sometimes needs surgical intervention.

52
Q

Describe encephalitozoon cuniculi

A

A fungal obligate intracellular pathogen that has high prevalence in rabbits. Most infections are chronic and subclinical. Transmitted horizontally and vertically. Spores are excreted in urine. Zoonotic but no evidence of rabbit -> human spread. Targets the kidneys, CNS, ocular tissues; causes vestibular signs, phacoclastic uveitis, chronic renal disease. Diagnose with clinical signs and serology (IgG, IgM, CRP). Can do antigen detection, but intermediately shed. Treat with fenbendazole (CAUTION- leukopenia), anti-inflammatories, and supportive care

53
Q

What serious side effect is associated with fenbendazole in rabbits?

A

Leukopenia

54
Q

Describe spinal luxation and fracture in rabbits

A

Due to powerful hindlimbs, leads to paralysis or paresis. Usually in lumbosacral region due to improper handling or trauma. Differentials include intervertebral disc disease and neoplasia, but these are not usually as acute. Diagnose with deeply sedated rads or CT. Treat with supportive care and cage rest, surgical fixation difficult, prognosis variable.

55
Q

Describe splay leg in rabbits

A

A developmental problem that is often bilateral and can occur in hind or front legs. Can occur in young or old rabbits, leads to luxation and valgus deformity. Treated with corrective hobbling or by removing and treating cause (slippery floor, obesity, sedentary lifestyle)

56
Q

What type of virus causes rabbit hemorrhagic disease virus? Where does it occur?

A

A calicivirus. Endemic in Europe, emerging in the US. REPORTABLE

57
Q

What does rabbit hemorrhagic disease virus present as?

A

Fatal hepatitis and DIC-like condition. May see pyrexia, circulatory shock, GI signs, CV signs, neurologic signs, epistaxis, rapid progression, and sudden death.

58
Q

How is RHDV transmitted?

A

Direct contact, fomites, bodily fluids, vectors, also highly resistant in environment

59
Q

What are the two types of RHDV?

A

Type 1- European rabbits (mostly older), high mortality, not in US
Type 2- European and wild rabbits of all ages, variable mortality, emerging in US

60
Q

How is RHDV prevented?

A

Vaccine in Europe, quarantine, biosecurity, environmental cleaning, restrict outdoor exposure

61
Q

Describe myxomatosis

A

A myxoma virus used for overpopulation control in Australia. Affects wild and domestic rabbits, transmitted by direct contact and biting arthropods. Vaccine available in Europe. Causes cutaneous fibromas, facial swelling, ocular discharge, skin nodules, pyrexia, lethargy and systemic disease- highly fatal! No treatment