Acne

Question 1

What is acne?

Answer 1

Chronic inflammatory skin condition (spots)

Question 2

Two type of non-inflammed acne lesions?

Answer 2

Open comedone - aka black heads.
Closed comedones - aka white heads.

Question 3

Characteristcs of severeity in acne

Answer 3

1. Mild - mainly non-inflamed lesions.
2. Moderate - mixed inflamed and non-inflamed lesions.
3. Severe - inflamed acne +/- scaring.

Question 4

Class of medication if benzoyl peroxide

Answer 4

Topical Antibiotic

Question 5

Mechanism of action of benzoyl peroxide?

Answer 5

bactericidal against Cutibacterium acnes,
Nitrogen binding, kills bacteria that cause acne.
Also remove dead skin cells (i.e., skin peeling)

Benzoyl peroxide, once absorbed by the skin, is converted to benzoic acid.

Approximately 5% of the benzoic acid is systemically absorbed and excreted by the renal system

Question 6

Side effects of benzoly peroxide

Answer 6

Skin irritation - stingy, burning, ithcing.

Question 7

benzoly peroxide contraindications / precautions?

Answer 7

Sunburn
UV light
Prego
Breast feeding.

Question 8

Adapalene class of drug?

Answer 8

retinoid-like compounds

Question 9

Mechanism of action of Adapalene?

Answer 9

moderates cellular differentiation, keratinization, and inflammatory processes

Question 10

Contraindications of Adapalene?

Answer 10

pregnancy, photosensitive disorder,
eczema,
sunburn,
or concomitant use of other potentially irritating skincare products
Hydrocephalus (idiopathic increase Intracrainial pressure)

Question 11

Tretinoin class of drug?

Answer 11

Retinoid

Question 12

Mechanism of action of Tretinoin?

Answer 12

increases mitotic activity –> increase cell turnover. –> skin shedding/peeling. Comedomes can be expelled.

Question 13

Side effect of Tretinoin?

Answer 13

Local skin irritation.
lightening of normal skin color.

Question 14

C

Answer 14

P

Question 15

Clindamycin class of drug?

Answer 15

(macrolides) lincomycin antibiotics

Question 16

Mechanism of action of clindamycin?

Answer 16

binding to the 50s ribosomal subunit of bacteria –> inhibit protein syn and bacterial growth.

Bacteriostatic

Question 17

Side effects of clindamycin?

Answer 17

Metalic taste
Joint pain

Question 18

Tx options of Mild to moderate acne + length + frequnecy?

Answer 18

All Topical
3/12
OD Nocte

1. Adapalene + Benzyl peroxide
2. Tretinoin + clindamycin
3. Benzyl peroxide + clindamycin

Question 19

Tx for Moderate - severe acne + Length?

Answer 19

3/12
1. Topical Adapalene + benzyl peroxide

2. Topical Tretinoin + Clindamycin
3. Topical Adapalene + Benzyle peroxide + PO antiBx (Lymecycline OR Doxycyline)
4. Topical Azeilic acid + Po AntiBx (lymecycline OR doxycycline)

Question 20

Lymecycline class of drug?

Answer 20

tetracycline antibiotic

Question 21

Mechanism of action of Lymecycline?

Answer 21

binds to the 30S ribosomal subunit

Question 22

Lymecycline contraindications?

Answer 22

renal tubular acidosis or hepatic toxicity.
Avoid in renal and liver pts.

Question 23

Doxycycline drug class

Answer 23

Tetracycline antibiotics.