Flucloxacillin

Question 1

drug classification

Answer 1

narrow spectrum antibiotic
penicillin
B-lactam

Question 2

chemical structure

Answer 2

contains a beta lactam ring
resembles tetra peptide chain

Question 3

brand name

Answer 3

floxapen
fluclox

Question 4

bioavailability

Answer 4

50-70%

Question 5

used to treat

Answer 5

bacterial infection caused by gram positive bacteria

Question 6

mechanism of action

Answer 6

binds to transpeptidase which is a penicillin binding protein inside the bacterial cell wall
inhibits 3rd and last stage of cell wall synthesis
prevents the PBPs from cross-linking the D-ala-D-ala chain on a tetra peptide

Question 7

what happens when there’s no cross linking in peptidoglycan

Answer 7

wall becomes weak
cell lyses occurs by autolytic enzymes such as autolysins
hydrolyse mucopeptide polymers in bacterial cell wall
if they attempt to divide their cell walls will collapse
kill them

Question 8

side effects for normal penicillins

Answer 8

D&V
nausea
skin reactions
hypersensitivity
thrombocytopenia

Question 9

side effects of flucloxacillin

Answer 9

gastrointestinal disorders
allergy presenting as a skin rash
anaphylactic reactions, hypotension, bronchospasm