Calcium Channel Blockers Flashcards
What are the 3 classes of CCB? Examples?
Phenylalkylamines -verapamil
Dihydropyridines - nifedipine, amlodopine
Benzothiazepines - diltiazem
Which CCB do we avoid in HF?
Verapamil, diltiazem
Which CCB needs to be maintained on the same MR brand? Why
Nifedipine
Diltiazem- prescribe by BRAND! Because different MR preps above 60mg have different clinical effect
SE of CCB
Flushing
Headaches
Postural hypotension
Oedema!!
GI disorders
Skin reactions
Which CCB are not used in arrhythmias and why?
Dihydropyridines - lercanidipine, amlodopine, felodopine
Because they have no anti-arrhythmic activity
CCB MOA
relax muscular smooth muscles
Which CCB is highly negatively inotropic? What does this mean?
Verapamil
Slows down HR alot
…. Is less negatively inotropic than ….
Diltiazem
Verapamil
Which CCB is a cardiac depressant and has vasodilatory effects
Diltiazem
Which CCB may precipitate HF
Verapamil
Do CCB reduce myocardial infarction risk in angina?
No
In unstable angina BB are used, in those resistant to them, whats the alternative?
Verapamil and diltiazem
How do you withdraw CCB? Why?
Slowly because they have vasodilatory effects hence can cause angina/ MI if abruptly withdrawn
Nicorandil indication
What others are used for this indication
Long term treatment of angina others include ivabradine and ranolazine
What class is nicorandil?
Potassium channel activator with nitrate component
