VBS 4 Pharm Flashcards
1
Q
Radioactive Iodine (I-131) MOA
A
- I-131 IV admin
- emitted radiation destroys surrounding functioning follicular cells
- minimal damage to bordering structures
2
Q
Atenolol Classification
A
- B1-adrenergic antagonist (Beta blocker)
- Class II antiarrythmic
- negative ionotroph
- negative chronotroph
3
Q
Atenolol MOA
A
- binds to B1 receptors in the heart
4
Q
Methimazole MOA
A
- anti-thyroid: inhibits thyroid peroxidase
- dose-dependent
5
Q
Propofol MOA
A
- decreases the rate of GABA dissociation from receptors
- enhances opening of Cl channels
- resulting in hyperpolarization of postsynaptic cell membranes and inhibition of postsynaptic neurons
6
Q
Alfaxalone MOA
A
- binds to GABA cell surface receptors
- enhances opening of Cl channels
- resulting in hyperpolarization of postsynaptic cell membranes and inhibition of postsynaptic neurons
7
Q
Enrofloxacin Classification
A
- fluoroquinolone antibiotic
- bacteriCIDAL
- concentration-dependent
- highly effective against Gram- aerobes, some Gram+ aerobes
8
Q
Enrofloxacin MOA
A
inhibits DNA gyrase (facilitates DNA replication or transcription)
9
Q
Enrofloxacin Adverse Effects
A
- cats: actue retinal degeneration
10
Q
Silver Sulfadiazine Classification
A
- sulfonamide antibiotic
- bacteriCIDAL
- Broad spectrum: Gram+/- bacteria, yeast/fungal infections
11
Q
Sulfonamides MOA
A
- disrupts cell wall and membrane
- inhibition of DNA replication
12
Q
Amikacin Classification
A
- aminoglycoside antibiotic
- treats serious Gram- infections
- bacteriCIDAL
- concentration dependent
13
Q
Amikacin MOA
A
irreversibly binds 30S ribosomal unit - inhibiting protein synthesis
14
Q
Amikacin Adverse Effets
A
- OTOtoxicity (8th cranial nerve lol)
- nephrotoxicity
15
Q
Meloxicam MOA
A
- NSAID: COX-2 preferential (NOT specific!)