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Sketchy Pharm > Antineoplastics > Flashcards

Antineoplastics Flashcards

1
Q

cladribine indication

A

hairy cell leukemia

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2
Q

gemcitabine

A

inhibit DNA pol
pyrimidine

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3
Q

cytarabine

A

inhibit DNA pol
pyrimidine

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4
Q

cladribine

A

inhibit DNA pol
purine

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5
Q

AMP, GMP

A

purine nucleotides

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6
Q

azathioprine

A

6-MP prodrug

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7
Q

6-MP is activated by ___

A

HGPRT

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8
Q

6-MP MOA

A

blocks IMP synthesis
(and thus AMP, GMP production)

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9
Q

6-MP indications

A

ALL
IBS
RA (refractory)

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10
Q

6-MP is inactivated by ___ and ___

A

XO
TPMT

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11
Q

mycophenolate mofetil

A

IMP dehydrogenase inhibitor

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12
Q

6-MP adverse effects

A

pancreatitis
hepatitis
myelosuppression

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13
Q

cyclophosphamide

A

DNA alkylating (cross-linking) agent

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14
Q

how to activate cyclophosphamide

A

CYP 450

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15
Q

cyclophosphamide adverse effects

A

hemorrhagic cystitis
SIADH
infertility

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16
Q

___ prevents hemorrhagic cystitis with cyclophosphamide use

A

mesna

17
Q

cyclophosphamide increases risk for ___ ___

A

bladder cancer

18
Q

busulfan

A

transplant immunosuppresant
DNA alkylating agent

19
Q

streptozocin indication

A

GBM
(easily cross BBB)

20
Q

INF-B indication

A

MS

21
Q

INF-gamma indication

A

CGD

22
Q

-platin MOA

A

cross-link with platinum

23
Q

antineoplastic that causes ototoxicity

A

cisplatin

24
Q

cisplatin is ___toxic

A

nephro
(and ototoxic)

25
Q

___ prevents cisplatin-induced nephrotoxicity

A

amifostine

26
Q

amifostine MOA

A

free radical scavenger

27
Q

-poside

A

topoisomerase II inhibitors

28
Q

-tecan

A

topoisomerase I inhibitors

29
Q

-taxel MOA

A

prevent microtubule degradation and increase improper production

Sketchy Pharm (7 decks)

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