Psychopharmacology Flashcards
1
Q
Mechanism of action of typical antipsychotics
A
Dopamine receptor blockade = D2 antagonists
2
Q
SE of typical APs
A
- Hyperprolactinaemia
- Extrapyramidal = pd, akathasia, dystonia, dyskinesia
- Metabolic SE = weight gain, T2DM
- Anticholinergic SE = tachy, vision, constipation
- Neuro SE = NMS, seizures
3
Q
Mechanism of action of atypical APs
A
- Also block 5HT2 (serotonin) receptors
- More selective
4
Q
Clozapine
A
- Agranulocytosis
- Lowers seizure threshold
- FBC weekly then 2w then monthly
5
Q
The 4 dopamine pathways
A
- Mesolimbic (+ve sx)
- Mesocortical (-ve sx)
- Nigrostriatal (EPS and TD)
- Tuberinfundibular (prolactin)
6
Q
Which pathway causes hyperprolactinaemia
A
tuberoinfindibular
7
Q
Which pathway causes EPS and TD
A
- nigrostriatal
8
Q
SE SSRI
A
- N+V
- headache
- agitation, anxiety
- Sexual dysfunction
- Insomnia
- Hyponatraemia
9
Q
SNRI SE
A
- Nausea
- Dry mouth, dizzy
- Headache
- Sweat
- HTN
10
Q
Lithium monitoring
A
- 0.6-1
- 1 after start, 1w after dose change and weekly until stable then 3m
- 12hrs post dose
- 6m thyroid, parathyroid, renal
- weekly plasma
11
Q
Lithium SE
A
- Nausea
- Diarrhoea
- Muscle weakness
- Hypo/hyperthyroid
- Tremor fine
- weight gain
- polyuria and dipsia
- Hyper PTH
- Nephro
12
Q
lithium toxicity
A
- drowsy
- N+V
- blurred vision
- coarse tremor
- delirium
- dysarthria
