Ion Channel Inhibitors

Question 1

Amantadine
MOA

Answer 1

M2 inhibitor that prevents the uncoating of influenza A virus and consequently its replication in the host cell

Question 2

Amantadine
Abs/Distrb/Elim

Answer 2

Given as a tablet or syrup
Bioavailability 66% to 100%
Glomerular filtration and renal tubular secretion

Question 3

Amantadine
Clinical use

Answer 3

Influenza A
There is considerable resistance to M2 inhibitors in Influenza A; neuraminidase inhibitors are favoured.

Question 4

Amantadine
Adverse effects

Answer 4

Lightheadedness, difficulty concentrating, insomnia, fatigue, slurred speech, loss of appetite, and nausea