Receptor Review Flashcards
0
Q
TGF-beta binds what receptors?
A
Those with ser/thr kinases leading to SMAD activation
1
Q
Ras/MAPK and Ras/PKB lead to what cell functions?
A
Cell growth and proliferation. Inhibition of apoptosis
2
Q
IFN and IL activate what pathway?
A
JAK/STAT
3
Q
Detail the erithropoitein activation pathway
A
Epo to EpoR to JAK2 to STAT5 to Tx activation
4
Q
Cushing syndrome is assoicated with what?
A
GR
5
Q
Familial early-onset hypertension
A
MR
6
Q
Breast cancer
A
ER
7
Q
AIS, Kennedy’s disease, prostate cancer
A
AR
8
Q
GRTH syndrome
A
TR
9
Q
Hypocalcemic vit-D resistant rickets
A
VDR
10
Q
Acute promyelocytic leukemia
A
RAR
11
Q
Cholera
A
Gs-alpha
12
Q
Whooping cough
A
Gi-alpha
13
Q
Familial hypertrophic cardiomyopathy
A
Ca+2
14
Q
Noonan and Costello syndromes
A
Ras
