PSORIASIS

Question 1

defnition of psoriasis

Answer 1

Sharply demarcated erythematous plaques with micaceous scale

Question 2

genes that cause psoriasis x2

Answer 2

HLA-Cw6
Psoriasis susceptibility regions PSORS1-9

Question 3

what cells cause psoriasis

Answer 3

T cells which turn into

T helper 1, 17 &22

Question 4

what does psoriasis do to the cell cycle

Answer 4

reduced from 28 days to 3-5

Question 5

what does psoriasis do to nails

Answer 5

Onycholysis, pitting, oil spots

Question 6

what age does glute psoriasis occur

Answer 6

children and adolescents

Question 7

psoriasis on just hands and feet

Answer 7

Palmo-plantar Psoriasis, or pustulosis

Question 8

what psoriasis tends to occur in flexures, has less scale
and is triggered by infections

Answer 8

Flexural / Inverse Psoriasis

Question 9

what type of psoriasis has Sterile pustules, sometimes systemic symptoms

what causes it x4

Answer 9

Pustular Psoriasis

Pregnancy
or after rapid taper/stop steroids
hypocalcaemia
infection

Question 10

what type of psoriasis causes:
more than 80% of body surface area in erythematous, with fine scale
fever and low blood pressure

treatments x3

Answer 10

Erythrodermic psoriasis- ‘Red Man’ syndrome

-FLUID BALANCE
-Bloods / IV access
-Thick greasy ointment emollients

Question 11

primary care for psoriasis x6

Answer 11

Emollients, Creams vsOintments
Soap substitutes
Vitamin D3 analogues
Coal Tar creams
Topical Steroid
Salicylic acid (keratolytic)

Question 12

secondary care for psoriasis x7

Answer 12

Crude Coal Tar
Dithranol
UVB Phototherapy
Oral retinoids- Acitretin

Immunosuppression: Methotrexate
Small Molecules
Biologic Therapies