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PHA313 > NMJ Blockers > Flashcards

NMJ Blockers Flashcards

1
Q

Classified based on

A

Duration of action
Mechanism of action
Chemistry

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2
Q

Mechanism of action

A

Long acting
Intermediate acting
Short acting

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3
Q

Long acting

A

D-tubocurarine
Pancuronium
Doxacurium
Metocurine

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4
Q

Intermediate acting

A

Vecuronium
Rocuronium
Atracurium

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5
Q

Short acting

A

Mivacurium

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6
Q

Based on chemistry

A

Natural alkaloids
Ammonio steroids
Benzylisoquinolines

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7
Q

Natural alkaloids

A

D-tubocurarine
Semi-Synthetic alkaloid = Alcuronium

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8
Q

Ammonio-steroids

A

Pancuronium

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9
Q

Benzylisoquinolines

A

Atracurium
Mivacurium

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10
Q

Based on mechanism of action

A

Competitive (non-depolarizing)
Depolarizing

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11
Q

Competitive (non-depolarizing) example

A

D-tubocurarine

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12
Q

Depolarizing example

A

Succinylcholine
Decamethonium

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13
Q

Xtics of non-depolarizing blockers

A
  • Bind to receptors and prevent NT binding, prevent depolarization
  • Poorly absorbed
  • Rapidly excreted
  • Slow onset of action
  • Long duration of action
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14
Q

Non-depolarizing examples

A

Pancuronium
Atracurium
Mivacurium
Vecuronium

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15
Q

Depolarizing blockers

A

Succinylcholine
ACh

They are depolarizing agonists in excess

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16
Q

How are agonists like succinylcholine NMB blockers?

A

They are more resistant to AChE action and polarize more persistently.

17
Q

Adverse effect of d-tubocurarine

A

Fall in arterial pressure due to ganglion block and release of histamine, causing brochospasm

18
Q

How is tachycardia an adverse effect in NMB block?

A

It is due to ganglion blockade and histamine release

19
Q

NMBs that cause tachycardia

A

Atracurium
Mivacurium
Pancuronium
Gallamine
Tubocurarine

20
Q

Adverse effects of NMBs

A
  • Tachycardia
  • Bradycardia (succinylcholine, M2 action)
  • Increased intraocular pressure
  • Prolonged paralysis (succinylcholine, enzyme inhibition)
  • Malignant hyperthermia
21
Q

Clinical uses of NMBs

A
  • Surgical relaxation
  • Tracheal intubation
  • Control of ventilation
  • Treatment of convulsion (peripheral manifestation)

PHA313 (5 decks)

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