T-Cell Immunity - Poholek Flashcards
Main Functions of CD4 T-helper cells
Secrete cytokines to direct other immune cells and recognize antigen presented by APCs in the context of MHC-II
Main functions of CD8 Cytotoxic T-cells
Directly kill target cells and recognize antigen presented by APCs in the context of MHC-I
Main target of Th1 cells
Targets intracellular microbes (mycobacteria, viruses, toxoplasma)
What does IFN-gamma do?
Drive macrophage activation, complement binding, increases MHC processing, and inhibit viral replication by upregulating defense genes.
What cytokine drives development of Th1 cells? What txn factor is the master regulator?
IL-12 and T-bet
What do Th2 cells target?
Extracellular parasites
Primary effector cytokines of Th2 cells
IL-4, IL-5, IL-13
Master txn factor of Th2 cells
GATA3
Th2 mediated immunopathology
- Skin allergies
- Food allergies
- Seasonal Allergies
*IgE/Mast cell mediated
Allergic Asthma: Recruitment of eosinophils to the lungs and mucus secretion/restriction by IL-5
Target of Th17 cells
Primarily fungus
Cytokines produced by Th17 cells
IL-17 and IL-22
Th17 cell Differentiation
Inducible txn factor: STAT
Master Regulator: RORyt
Th17 cell driven autoimmune diseases
Psoriasis
Most/all autoimmune diseases as well
Where do TfH cells have their effector function?
In the germinal center
Effector cytokine of Th1 cells
IFN-gamma
