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crozer surgery keegan duelfer > Wound Care > Flashcards

Wound Care Flashcards

1
Q

What are the stages of wound healing (3)

A

Inflammatory phase

Proliferative phase

Remodeling phase

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2
Q

Inflammatory phase
-time frame
-what occurs
-cells involved

A

days 1-4
-initial vasoconstriction followed by vasodilation
-neutrophils and macrophages are recruited

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3
Q

Proliferative phase
-time frame
-what occurs
-tensile strength at 14 days

A

days 3-21
-collagen synthesis provides tensile strength of wound
-at 14 days, tensile strength of wound equals that of suture

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4
Q

remodeling phase
-time frame

A

days 21 up to one year

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5
Q

At what stage of healing do chronic wounds stop progressing

A

at the proliferative phase

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6
Q

What is santyl

A

collagenase- an enzymatic debrider that digests collagen in necrotic tissue

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7
Q

What is Regranex

A

PDGF-1

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8
Q

Where is Regranex made

A

Puerto Rico

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9
Q

What is a normal value for serum albumin

A

3.4-5.0 g/dL

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10
Q

What is a low serum albumin level associated with (5)

A

-decreased wound healing
- edema
-impaired cellular immunity
-decreased collagen synthesis
-decreased fibroblast proliferation

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11
Q

What minimum ABI is necessary for wound healing

A

.35 for non-diabetic

.45 for diabetic patient

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12
Q

How does negative pressure wound therapy assist wound closure

A

negative pressure wound therapy applies mechanical shear stress to the wound site. This is believed to promote granulation by decreasing bacterial bioburden, reducing edema, and inducing capillary budding

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13
Q

How does hyperbaric oxygen therapy assist wound closure

A

Hyperbaric oxygen therapy increases the partial pressure of O2 in arterial circulation, which increases diffusion of O2 at the wound site. This is believed to increase growth factors promoting angiogenesis and collagen synthesis.

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14
Q

What is integra

A

bilayer graft composed of bovine tendon collagen with chondroitin 6- sulfate and a silicone layer to control moisture loss

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15
Q

What is oasis

A

extracellular graft matrix derived from porcine, small intestine submucosa

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16
Q

What is apligraf

A

bilayer graft derived from neonatal foreskin with dermal and epidermal layers

17
Q

What is graft jacket

A

extracellular graft matrix derived from human tissue with intact vascular channels

18
Q

What is tissue mend

A

acellular collagen matrix derived from fetal bovine dermis

19
Q

Inflammatory Phase: 3 parts

A

-Vascular
-Hemostatic
- Cellular

20
Q

Inflammatory Phase Vascular component

A

1)Vasoconstriction of the blood vessels. Fibrin promotes hemostasis and provides scaffolding for the ingrowth of cells at a later stage.

2)Vascular permeability: achieved through histamine (vasodilator)

Serotonin and kinins also increase the permeability

21
Q

Neutrophils: when they get there, peak numbers, function

A
  • Arrive at the wound in 6 hours
    -Peak numbers occur at 1-2 days
    -Responsible for wound debridement with the release of callagenolytic and fibrinolytic enzymes. Neutrophiles also ingest bacteria
22
Q

Lymphocytes: peak numbers. Most important roles.

How they attract and activate macrophages

A

-Reach peak numbers in 6 days

-most important role is in the synthesis of lymphokines

-Migration Inhibition factor (MIF): attracts macrophages to the wound

-Macrophage Activation Factor (MAF): activates the macrophage

23
Q

Macrophages:
Reasons why they are the most important cell for wound healing (4)

A

1) only cells able to tolerate low O2 tension at the wound edge

2)Appear in the wound during first 5 days and have a long life span

3)Wound healing severely limited by their absence

4)Process and presents antigens to the lymphocytes

24
Q

-Cells that produce collagen
-When does collagen synthesis begin
-What is fibronectin and what does it do (3)

A

-Migratory fibroblasts (mesenchymal cells) produce collagen

-Collagen synthesis begins on the 5th day and lasts for 2-4 weeks

-Fibronectin (produced by fibroblasts)
— Coats macrophages to aid in opsonization and phagocytosis
— Found on surface of fibroblasts where it aids in the adhesion of these cells to the ECM
—Fibronectin corss lings with collagen and glycosaminoglycans

25
Q

Proliferative phase: 3 parts

A

-Epidermal regeneration
-Neoangiogenesis
- Collagen synthesis

26
Q

Epidermal regeneration components
-cells at wound edge
-fibronectin network
- basement membrane

A

-Cells at wound edges flatten out to develop pseudopods to migrate at a rate directly proportional to oxygen tension of the tissue (hyperbaric)

-Fibrin- fibronectin networks serves as a framwork over which this migration can occur

-Basement membrane under epidermal cells begin to change
—Epidermal cells elongate in direction of the wound
—mitotic activity of epidermal cells increases
—division and movement of epidermal cells under the direction of epidermal growth factor

27
Q

Neoangiogenesis

-timing of new capillary buds
- Capillary formation influenced by
-oxygen’s role

A

-Formation of new cap buds near the wound occurs at same time as migration of epidermis

-development of capillaries toward center of wound is under influence of growth factors from macrophages

  • As O2 tension increases with formation and opening of new vascular channels the growths factors are inhibited
28
Q

Collagen synthesis
-relation to O2 tension
-maximum levels

A

-As O2 tension further increases fibroblasts begin synthesizing collagen

-Amount of collagen reach maximum levels at 2-3 weeks post injury

29
Q

Remodeling phase:
-how long it takes
-2 weeks tensile
-1 month tensile
-Equilibrium
-Wound contraction

A

-lasts up to 1 year
-2 weeks: 35% tensile strength
-1 month: 40-50% tensile
-Entire remodeling an equilibrium between lying and resorbing old collagen and formation of new collagen.

  • Wound contraction is a part of healing. Contraction progresses at .6mm-.7mm/day
30
Q

Healing by 1st intents (8 steps)

A

1-narrow incision space immediately fills with clotted blood containing fibrin and blood cells

2- Dehydration of surface clot forms a scab

3- Within 24 hours neutrophils appear on the margin of wound

4- Within 24-48 hours the cut edges thicken from mitotic activity of basal cells.
—-epithelial cells from edges migrate along cut margins of the dermis to deposit basement membrane as they move

5- Day 3 Neutrophils replaced by macrophages
—increased granulation tissue at incision site
—collagen fibers begin to be manufactured
— thin epithelial cell layer thickens

6- Day 5: neovascularization is maximal. Epidermis back to original thickness

7-During 2nd week there is increased collagen and fibroblast activity

8-End of 1st month a scar starts to develop
—maximum tensile strength developed in several months

31
Q

Factors that interfere with wound healing (8)

A

-age
-inadequate perfusion
-edema
-infection
-poor nutrition
-vitamin deficiencies
-steroids and cytotoxic meds
-radiation

32
Q

5 growth factors important in wound repair

A

PDGF: platelet derived growth factor

PDAF: platelet derived angiogenesis factor

PDEGF: Platelet derived epidermal growth factor

TGFB: transforming growth factor beta

Platelet factor 4

33
Q

Types of compression therapy (5)

-pressure achieved
- reason for use

A

Antiembolism stockings
–16-18mmHg. For DVT prophylaxis

Low compression
—18-24mmhg. Non-ambulatory patients

Low to Moderate compression
—25-35mmHg for edema secondary to venous insufficiency

Moderate compression stockings
—30-40mmHg. For edema with or without ulcer

High compression stockings
—40-50mmHg for lymphedema

34
Q

Split thickness grafts
3- size and advantages

A

Thin: .008-.012inches
-excellent host tissue incorporation but a lot of contraction occurs

Intermediate: .012-.016inches
-more durable, contracts less but slightly less incorporation as well

Thick: .016- .02 inches
-Less chance of host incorporation but durability and contraction much improved

35
Q

Skin graft complications (3)
-what are they
-how to prevent

A

Seroma: most common
-transudative fluid accumulation
-prevented through pressure dressing and pie crusting

Hemotoma:
-blood collection
-normal capillary bleeding necessary, to prevent need proper fenestration/pressure dressing application

Infection:
-strep pyogens and pseudomonas pyocyanes produce fibrinolysin which will disrupt fibrin bone and devastate the graft

36
Q

Stages of skin graft healing (4)

-Timing and what occurs

A

Plasmatic stage:
-occurs 24-48 hours
-fibrin layer forms between graft and host bed to anchor and allow diffusion of nutrients

Inosculation Stage:
-begins at 48 hours
-revascularization of grafted tissue
-Lymph drainage established 4th-5th day

Reorganization stage
-continues for months
-connective tissue reorganizes and regulates vascular and lymphatic flow

Re-innervation:
-Occurs simultaneously with reorganization stage
-Process takes one-two years to complete

crozer surgery keegan duelfer (16 decks)

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