benzo Flashcards
1
Q
a1 GABAa receptor subtype
A
sedation, amnesia, anticonvulsant
2
Q
a2 GABAa receptor subtype
A
CNS (spinal cord( mediated skeletal muscle relaxant and anxiolysis
3
Q
GABA receptor saturation 20%
A
anxiolysis
4
Q
GABA receptor saturation 40%
A
sedation
5
Q
GABA receptor saturation 60%+
A
unconsciousness
6
Q
benzo structure
A
all benzo:
-benzene ring fused to 7 member diazepam ring
all important benzo have:
-5-aryl substituent in their structure
7
Q
aryl halide
A
an aromatic derivative in which a ring hydrogen has been replaced by a halide atom
8
Q
Benzo potency is a function of…
A
receptor affinity
