Oral Absorption - PreLecture

Question 1

What is route of an orally absorbed drug?

Answer 1

1. Absorbed from GIT through gut wall
2. Portal vein
3. Liver
4. Systemic circulation and site of action

Question 2

What is the difference between FA and F?

Answer 2

FA: faction of drug absorbed from gut wall to portal vein
F: Bioavailability where a drug is bioactive at the site of action

Question 3

What order is the drug transfer from GIT to body?

Answer 3

zero or first

Question 4

What is the order of drug elimination of oral absorption?

Answer 4

first

Question 5

Describe the compartmentalization of oral absorption?

Answer 5

Question 6

What is the equation for 0 order oral absorption?

Answer 6

Question 7

What is the equation for 1st order oral absorption?

Answer 7

Question 8

What are the phases of drug absorption?

Answer 8

1. Absoprtion
2. Peak drug concetration
3. Post absorption phase
4. Elimination phase

Question 9

When does elimination occur?

Answer 9

As soon as absorption starts

Question 10

What rate is great absorption or elimination prior to Cmax?

Answer 10

Absorption

Question 11

What occurs at peak drug concentration?

Answer 11

1. Tmax
2. Drug absorption is equal to elimination

Question 12

When does post-absotion phase occur?

Answer 12

Immediately after Cmax

Question 13

What rate is great absorption or elimination post Cmax?

Answer 13

elimination

Question 14

What occurs during the elimination phase?

Answer 14

1. Absorption depletes and rate approaches zero
2. Elimination rate is great
3. Point plasma concentration declines and behaves like IV bolus

Question 15

If ka increases (while k is unchanged) what are the effects on Tmax, Cmax and AUC?

Answer 15

a. Tmax decreases
b. Cmax increases
c. AUC is unchanged

Question 16

If k increases (while ka is unchanged) what are the effects on Tmax, Cmax and AUC?

Answer 16

a. Tmax decreases
b. Cmax decreases
c. AUC decreases