Medication Treatments Flashcards

1
Q

Scz 1st line

A
  • AP. No established clinical superiority of one.
  • Consider LAI early.
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2
Q

Scz trial

A
  • If no response at 4 weeks, change medication.
  • If a partial response, r/a at 8 weeks unless sig interval change.
  • Trial: 6 weeks at optimized dose.
  • Following resolution of (+) sx, tx should ctn for 18 months.
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3
Q

Mania monotherapy 1st line

A

DVP, Li
Abilify, Asenapine, Seroquel, Risperidone, Paliperidone, Cariprazine

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4
Q

Mania combo therapy 1st line

A

DVP/Li + Abilify/Asenapine/Risperidone/Seroquel

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5
Q

Bipolar I depression 1st line, mono and combo

A
  • Mono: Seroquel, Li, Latuda
    (adj) Lamotrigine
  • Combo: Li/DVP + Latuda
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6
Q

Bipolar I maintenance monotherapy 1st line

A

DVP, Li, Lamotrigine
Abilify (po/IM), Asenapine, Seroquel

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7
Q

Bipolar I maintenance combo therapy 1st line

A

DVP/Li + Seroquel/Abilify

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8
Q

Bipolar II hypomania

A
  • No specific recommendations. Refer to mania.
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9
Q

Bipolar II depression 1st/2nd line

A
  • First line: Seroquel
  • Second line: Li, Lamotrigine, Bupropion (adj), Sertraline, Venlafaxine, ECT (level 3)
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10
Q

Bipolar II maintenance 1st line

A

Seroquel (level 1)
Li, Lamotrigine (level 2)

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11
Q

Bipolar II maintenance 2nd line

A

Venlafaxine (level 2)

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12
Q

GAD 1st line

A
  • Escitalopram, Paroxetine (+CR), Sertraline
  • Venlafaxine XR, Duloxetine
  • Pregabalin
  • Aglomelatine
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13
Q

Social anxiety disorder 1st line

A
  • Escitalopram, Fluvoxamine CR, Paroxetine (CR), Sertraline
  • Venlafaxine XR
  • Pregabalin
  • If performance only, consider beta blocker
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14
Q

Panic disorder/Agorophobia 1st line

A
  • Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine (CR), Sertraline
  • Venlafaxine XR
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15
Q

Specific phobia 1st line

A
  • Medications generally not recommended
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16
Q

MDD 1st line

A
  • Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline
  • Bupropion
  • Duloxetine, Venlafaxine, Desvenlafaxine, Milnicepran
  • Mirtazapine
  • Vortioxetine
  • Aglomelatine
  • Minaserin
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17
Q

OCD 1st line

A
  • Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline
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18
Q

MDE 2nd line

A
  • TCAs
  • Trazodone
  • Seroquel
  • Vilazadone
  • Moclobemide
  • Selegiline transdermal
  • Levomilnicepram
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19
Q

MDD with anxious distress

A

Use a med with efficacy in GAD (level 4)

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20
Q

MDD with catatonic features

A

Benzos (level 3)

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21
Q

MDD with melancholic features

A

No specific recommendations (level 2)

22
Q

MDD with atypical features

A

No specific recommendations (level 2)

23
Q

MDD with psychotic features

A

Use an AD with an AP (level 1)

24
Q

MDD with mixed features

A

Ziprasidone (level 3)
Lurasidone (level 2)

25
Q

MDD with seasonal pattern

A

No specific recommendations (level 2,3)

26
Q

MDD with cognitive dysfxn

A
  • Vortioxetine (level 1)
  • Bupropion, Duloxetine, SSRIs (level 2)
  • Mocolobemide (level 3)
27
Q

MDD with sleep disturbances

A
  • Aglomelatine (level 1)
  • Mirtazapine, Seroquel, Trazodone (level 2)
28
Q

MDD 1st line adjunct

A

Abilify, Quetiapine, Risperidone
(all level 1)

29
Q

MDD 2nd line adjunct

A

Brexpiprazole, Olanz (level 1)
Bupropion, Li, Mirtaz, Modafinil, Triiodothyronine

30
Q

Mania 2nd line

A

In order of hierarchy
- Olanz
- Carbamazapine
- Olanz + Li/DVP
- Li + DVP
- Ziprasidone
- Haldol
- ECT (BF)

31
Q

Mania with anxious distress

A

DVP, Seroquel, Olanz -> Carbamazapine

32
Q

Mania with mixed features

A

DVP + AAP

33
Q

Mania with psychotic features

A

Combo (mood stabilizer + AP) but no AAP has shown superiority

34
Q

Mania with rapid cycling

A
  • Discontinue AD and stimulants
  • No superiority of any 1st line treatments
35
Q

Bipolar I depression 2nd line mono

A

Cariprazine
DVP
ECT (RUL)

36
Q

Bipolar I depression 2nd line combo

A
  • Olanz + Fluoxetine
    (adj) SSRI/Bupriopion
37
Q

Bipolar I depression, severe (ie need a fast response)

A

1st line) Seroquel, Lurasidone

2nd line) ECT, Cariprazine, Olanz + Fluoxetine

38
Q

Bipolar I depression with anxious distress

A

Seroquel, Lurasidone, Olanz + Fluoxetine

39
Q

Bipolar I depression with mixed features

A
  • Will need a combo treatment
  • Avoid AD
40
Q

Bipolar I depression with melancholic features

A
  • No specific evidence
  • Experience suggests ECT
41
Q

Bipolar I depression with atypical features

A

Tranylcypromine + Li/DVP/AAP has some evidence

42
Q

Bipolar I depression with psychotic features

A

ECT and AAP effective

43
Q

Bipolar I depression rapid cycling

A
  • Avoid AD
  • No specific agents recommended
44
Q

Bipolar I maintenance monotherapy 2nd line

A

Olanzapine, Paliperidone (>6mg), Risperidone LAI (can also be adj)
Carbamazepine

45
Q

Bipolar I maintenance combo therapy 2nd line

A

Li/DVP + Lurasidone/Ziprasidone
(adj) Risperidone LAI

46
Q

Geri Bipolar I mania 1st/2nd line

A

1st) Li, DVP

2nd) Seroquel

TR) think clozapine, ECT

47
Q

Geri Bipolar I depression 1st/2nd line

A

1st) Seroquel, Lurasidone

2nd) Li, Lamotrigine (think ECT)

48
Q

Geri Bipolar I maintenance 1st/2nd line

A

1st) think about what you used in mania
Li, DVP, Lamotrigine

49
Q

PTSD 1st line

A
  • Sertraline, Paroxetine, Fluoxetine
  • Venlafaxine
50
Q

OCD 2nd line

A
  • Citalopram
  • Clomipramine
  • Mirtazapine
  • Venlafaxine
51
Q

OCD adjuncts

A

Abilify, Risperidone

52
Q

PTSD 2nd line

A
  • Fluvoxamine
  • Mirtazapine
  • Phenelzine