AP Exam 2

Question 1

If the pathologic lesions are expected to pass though the diaphragmatic plane, the best autopsy method to use is:

A. Letulle method
B. Virchow method
C. Rokitansky method
D. Ghon method

Answer 1

A. Letulle method

Question 2

The regulation of bone formation and resorption is controlled by a paracrine mechanism between the cellular components of bone. Inhibition of bone resorption is brought about by which process?

A. Increased RANK-to-Osteoprotegerin ratio
B. M-CSF pathway activation
C. RANK and RANK-ligand interaction
D. Activation of WNT/β-catenin signaling

Answer 2

D. Activation of WNT/β-catenin signaling

Question 3

20/M, cervical lymph node.
Immunostains show CK(-), LCA (-), CD3 (-), CD20 (+), CD15 (+), CD30 (+), PAX5 (nuclear, weak +) in the cells of interest.

The only extranodal site in which this tumor occurs frequently is:

A. Thymus
B. Kidney
C. Liver
D. Thyroid

Answer 3

A. Thymus

Question 4

29/F with multiple and predominantly unilateral masses

Diagnosis?

A. Trevor disease
B. Ollier disease
C. Multiple hereditary exostosis
D. Maffucci syndrome

Answer 4

B. Ollier disease

Question 5

40/F, modified radical mastectomy for breast mass.
How much percentage of the above histology must be present in order to diagnose the pure form of this variant?

A. 75%
B. 50%
C. 100%
D. 90%

Answer 5

D. 90%