Drugs

Question 1

Quinine interactions

Answer 1

(For malaria)
Levels increased by PI so hold
Increased vigilance for signs of quinine toxicity - may prolong QT

NNRTI may decrease quinine level needing dose titration

Question 2

Who can’t have mefloquine?

Answer 2

Those with hx epilepsy, neuropsychiatric disorders, liver impairment, cardiac conduction in disorders

Neurocog side effects more common in women, low bmi, long term travel, hx drug use
Particularly common in younger adults