Anti-Anginal medications and chronic coronary syndromes Flashcards
1
Q
Which medications decrease preload?
A
Nitrates
2
Q
- ** MOA:block andrenergic stimulation (NE release) to decrease cardiac work and myocardial oxygen consumption**
- Decrease HR, contractility and SBP at rest and SBP at rest and during exercise to delay or avoid ischemic threshold
- has cardioprotective benefits
- Antiarrhythmic properties
- lack of tolerance
A
Beta blockers
Carvedilol and Metoprolol are the most common
3
Q
Common side effects of beta blockers?
A
- Hypotension
- bradycardia
- heart block
- bronchospasms
- glucose intolerance (from non-vasodilating beta blockers)
- fatigue
- iniability to perform
- exercise
- impotence
- feeling cold
4
Q
- Indicated as initial treatment of reduction of symptoms whn BB are contraindicated or cause unacceptable side effects
- use in combination with BB when initial tx with BB is unsucessfull
- indicated as treatment for reduction of symptoms in patients with vasospastic angina
- MOA: block transmembrane calcium currents in vascular smooth muscle to cause arterial vasodilation
A
Calcium channel blocker
5
Q
what are some clinical benefits of calcium channel blocker?
A
- direct vasodilation of epicardial arteries to increase myocardial oxygen supply
- decrease myocardial oxygen demand by reduction of systemic vascular resistance and systolic pressure
- decrease myocardial oxygen demand by decreasing HR and contractility (Non-DHP)
