Sympatholytics

Question 1

What is the name for a1-adrenergic receptor antagonists?

Answer 1

Quinazolines
-end in “osin”

Question 2

What are the side effects of a1 receptor antagonists?

Answer 2

Orthostatic hypotension, inhibition of ejaculation, nasal stuffiness, tachycardia

Question 3

What are the non-selective a-adrenergic receptor antagonists?

Answer 3

Phenoxybenzamine [B-Haloalkylamines]
Phentolamine [Imidazolines]

Question 4

What is the name for a2-adrenergic receptor antagonists?

Answer 4

Yohimbine

Question 5

What are the non-selective B-adrenergic receptor antagonists?

Answer 5

Propanolol
Nadolol
Timolol
-useful for patients with liver/kidney issues
-taper-dose

Question 6

What therapeutic uses are there for B-adrenergic receptor antagonists?

Answer 6

-Hypertension, angina, cardiac arrythmias, mirgraine, stage fright, thyrotoxicosis, glaucoma, congestive heart failure

Question 7

What are the Non-selective B-adrenergic receptor antagonists that possess “Intrinsic Sympathomimetic activity”?

Answer 7

Cartelol, Pindolol
-partial agonists

Question 8

What are the B1-selective Beta Blockers?

Answer 8

-Cardioselective
-Metoprolol
-Bisoprolol
-Atenolol

Question 9

What are the contraindications of Beta Blockers?

Answer 9

Asthma, COPD, congestive heart failure

Question 10

What are the mixed a/B adrenergic receptor antagonists?

Answer 10

non-selective for B receptor antagonist
a1 selective antagonist
-Labetalol
-Carvedilol