Acneiform Questions Flashcards
What does acne consist of, and where is it normally found?
Consists of comedones, papules, pustules and nodules
Commonly found on the face, chest & back (where pilosebaceous units are common)
At what age does acne commonly present?
(commonly starts during puberty) due to an overactivity of oil glands
**concern for an androgenic tumor if severe acne is present at a young age (under 8 y/o, not including newborns)
What is the pathophysiology of acne?
(Chronic inflammatory condition driven by a hormonal component)
A combination of overactive oil glands and disruption of skin shedding will clog pores/collect bacteria (C. acnes)
The bacteria will cause inflammation which results in acneiform lesions
What is classified as mild acne?
Few papules, pustules, comedones
-limited (small in # and size)
-no nodules or scarring
What is classified as moderate acne?
Many papules, pustules, comedones
-more spread, more of a combination of all 3
-occasionally mild cystic/scarring (but NO PITTED scarring)
What is classified as severe acne?
Excessive papules, pustules, nodules
-deep pitted scarring
-many locations or just one severe location
(Genetics can also play a factor here)
What is papulopustular acne?
(papulo-) Papules and/or (-pustular) pustules
What is comedonal acne?
Open comedones (blackheads) and closed comedones (skincolored fine bumps, hard to pop unlike papules/pustules)
What is nodulocystic acne?
deep inflammatory lesions throughout the face
What does acne treatment depend on?
type and severity
also location, motivation of patient, cost/insurance
What are the topical treatments for mild-moderate acne?
Benzoyl Peroxide: reduces C.acnes (may cause redness/dryness and may cause bleaching of fabrics)
Topical Antibiotics (clindamycin): prevent growth of bacteria/anti-inflammatory (redness and dryness/ resistance possible, can cause C-diff if ingested)
Aczone Gel (topical dapsone): 12 years and over (adult female acne)
Retnoids (differin): increased cell turnover good for comedonal acne (irritation/dryness, thinning of skin can cause greater chance of sun burn)
What are the treatments for moderate-severe acne?
-topicals used for mild-moderate also used here
-antibiotics are temporary (should not be used long term)
Oral antibiotics: (decrease bacteria C. acnes/anti-inflammatory), commonly the tetracyclines
**avoid pregnancy
**side effects: vomiting/nausea/diarrhea/vertigo, rash
If cycline antibiotics: may cause grey staining of teeth/skin
What are some hormonal treatments for acne?
Combination birth control pills (estrogen-progesterone): oil gland inhibition
**risks for stroke, heart attacks, blood clots (ask about smoking, etc.)
Spironolactone: blocks androgen receptors
**nausea, vomiting menstrual irregularities, breast tenderness
**BLACK BOX WARNING: NO PREGNANCY
What are important patient education points for acne?
There is no cure, adherence is needed to see a difference (may take 6 weeks), limit picking, cleansing regimen, adjusting diet/skincare if necessary
Discoloration scarring will go away over time, pitted scarring will be permanent
When would you consider isotretinoin (accutane) as a treatment for acne?
If patient has severe nodulocystic acne as a last resort treatment, it will dry up oil glands
Generally monotherapy over 6 months, not using any other forms of treatment
-causing dryness & many other risky side effects
-Testing requirements: Serum HCG, Urine HCG, LFT, Cholesterol, triglycerides
**CATEGORY X BLACK BOX WARNING: NO PREGNANCY, IPLEDGE/CONSENT FORMS REQUIRED